Atopic Dermatitis

Question 0

contact dermatitis allergies

Answer 0

poision ivy

nickle

Question 1

3 classes of atopic dermatitis

Answer 1

1) contact aka allergic dermatitis
2) chronic irritant dermatitis
3) atopic dermatitis

Question 2

what type of HSR is contact dermatitis

Answer 2

IV

Question 3

systemic atopic dermatitis induced by cashews/mangos

Answer 3

baboon butt

Question 4

chronic irritatnt dermatitis

Answer 4

chronic exposure to irritant

burning and stinging (vs itchign in contact)

Question 5

patch test in irritant

Answer 5

negative (vs + in contact)

Question 6

atopic dermatitis

Answer 6

genetic disposition to special kind of skin reactivity that usually manifest in childhood
associated with IgE and defective water binding

Question 7

atopic dermatitis mostly mediated by

Answer 7

Th2

Question 8

3 phases of atopic dermatitis

Answer 8

acute
subacute
chronic

Question 9

hot spots for systemic atopic dermatitis

Answer 9

under arm
butt
waste band

Question 10

10% of atopic dermatitis patients also develop

Answer 10

asthma

Question 11

two types of defects that lead to atopic derm

Answer 11

defect in immunity

vs defect in barrier

Question 12

atopic dermatitis people dont do well in

Answer 12

heat!

wet/dry/wet/dry bad

Question 13

three theories of pathophys

Answer 13

cutaneous (outside in)
immunological (inside out)
neurovascular (pharm)

Question 14

cutaneous (outside in) theory

Answer 14

inc keratinization
decrease irritant threshold–>ichthyosis vulgaris and increase palmar linearirty

defective water bonding: asteatosis

LOF in fliaggrin gene–>dry skin

sweat retention, loss of antimicrobial peptide

Question 15

immunological pathophys

Answer 15

increase in Ige production +HSR to some env allergens, but hyposens doesnt work

so impaired t cell mediated

Question 16

neurovasc theory

Answer 16

increase periph vascular tone–>white demographism

increase in aden cyclase and camp abnormalities may increase release of inflammatory mediators

Question 17

physical findings of atopic

Answer 17

itching–>scratching–>dermatitis
superimposed bacterial infection is common
skin dry and scaly (esp with air)
facial pallor, cool extremities

Question 18

dennie’s lines

Answer 18

extra folds of lower eyelids

Question 19

atopic shiner

Answer 19

hyperpigmentation of lower lips

Question 20

ichthyosis vulgaris

Answer 20

dry skin secondary to protein defect

Question 21

changes with age

Answer 21

change from acute gneeralized itchy dermatitis–>itchiness and increased localization (joint flexure, hands, feet)–>thick skin and dry winter skin

Question 22

aggregavating factors

Answer 22

antigens: food, pollen–>increase IgE
increased sweating
excessive drying of skin (low humidity, bath)
clothing (esp wool) or no clothing (air drying)
infections
hormones
stress

Question 23

lab findings

Answer 23

70% have delayed blanch rxn with ach injection
moderate peripheral blood eosinophilia
food allergy

Question 24

complications

Answer 24

exfoliative dermatitis
premature cataracts
increased susceptinility for infections

Question 25

exfoliative dermatitis

Answer 25

total body redness and scaling

Question 26

tx

Answer 26

control triggers (LUBRICATE, use bath subsitute to decrease heat and drying of skin, derease stress)
antihistamines
compresses for crusted lesions
TSTs
abx to infx
uv light
macrolide-immune modulators
herbal therapy

Question 27

keratosis pliosis is bad because

Answer 27

infectiosn can get in