Atorvastatin

Question 1

Class

Answer 1

Lipid-lowering drug

Question 2

Action

Answer 2

Lowers LDL-C
Lowers plasma
triglyceride
Increase in HDL-C

Question 3

Mechanism of Action

Answer 3

Reversible competitive
inhibition of the rate
limiting enzyme HMG-CoA
reductase and thus
decrease in hepatic C
synthesis
Up regulates LDL receptors
Causes increased clearance
of LDL-C from plasma into
liver cells

Question 4

Clinical Use

Answer 4

Hypercholesterolaemia
Prevents atherosclerosis
Prevents cardiac infarction

Question 5

Adverse effects

Answer 5

Usually mild: muscle
pain, GIT
disturbances,
insomnia, rash
Severe myositis
Angioedema

Question 6

what is atorvastatin

Answer 6

selective, competitive HMG-CoA reductase inhibitor

Question 7

what does HMG-CoA reductase converts HMG-CoA into?

Answer 7

mevalonate

Question 8

in which pathway does HMG-CoA reductase converts HMG-CoA into mevalonate

Answer 8

in the cholesterol biosynthesis pathway

Question 9

The total cholesterol to HDL-C ratio is a what is the total chlesterol to HDL-C ratio a strong predictor of

Answer 9

coronary artery disease with and high ratios are associated with higher risk of disease

Question 10

why does Atorvastatin have greater LDL-lowering potency than other HMG-CoA reductase inhibitors.

Answer 10

Atorvastatin has a long half-life and hepatic selectivity