Aug 2014

Question 1

True/False: high-dose inactivate influenza vaccine (4x amount of hemagglutinin) is superior to standard dose inactivate influenza vaccine in older adults.

Answer 1

True - prevented hospitalisations, pneumonia, medication use etc.

Question 2

What is the most common neurological complication of sickle cell anaemia in children and how is it prevented?

Answer 2

Silent cerebral infarcts - prevented with regular blood transfusions.

Question 3

What is GS-5806?

Answer 3

GS-5806 is RSV entry inhibitor - Potential antiviral treatment for RSV.

Reduced the viral load and severity of disease in healthy adults subjected to RSV compared to placebo.

Question 4

What is Bedaquiline?

MOA?

When should it be avoided?

Answer 4

Used to treat refractory Mutidrug-Resistant Tuberculosis (MDR-TB) - novel agent that is a mycobacteria ATP synthetase inhibitor.

Should be avoided in patients with prolonged QTc

Question 5

In adenomas that undergoes resection, what is the determinant of long-term colorectal cancer mortality?

Answer 5

High-risk (worse) vs. Low risk adenoma (better)

Intuitive.

Question 6

What is considered a high-risk adenoma at risk of colorectal cancer?

Answer 6

High-grade dysplasia
Villous component
Size >10mm

Question 7

What is the rate of secondary transmission among household contacts of patients with Middle East respiratory syndrome coronavirus infection?

A. 1%
B. 5%
C. 10%
D. 25%

Answer 7

5%