Autoantibodies

Question 1

Antiphospholipid syndrome

Answer 1

Anti cardiolipin

Anti B2 glycoprotein

Question 2

Autoimmune hepatitis

Answer 2

Anti smooth muscle
Anti liver kidney microsomal 1 (Anti LKM-1)
Anti soluble liver antigen (anti SLA)

Question 3

Autoimmune Haemolytic Anaemia

Answer 3

Anti Rh blood group antigen

Question 4

Autoimmune thrombocytopenic purpura

Answer 4

Anti glycoprotein IIb/IIIa

Anti glycoprotein Ib/IX

Question 5

Churg-Strauss Syndrome (EGPA = eosinophilic granulomatosis with polyangitis)

Answer 5

P-ANCA angainst MPO

Perinuclear ANCA against myeloperoxidase

Question 6

Coeliac disease

Answer 6

Anti TTG

anti EMA

Question 7

Dermatitis Herpetiformis

Answer 7

Anti endomysial antibody (EMA)

Question 8

Dermatomyositis

Answer 8

Anti-jo-1 (t rna synthetase)

Question 9

Diffuse cutaneous scleroderma

Answer 9

Anti topoisomerase/Scl70

Anti RNA pol I / II / III

anti fibrillarin

Question 10

Good pastures syndrome

Answer 10

Anti GBM (glomerular basement membrane)

Question 11

Graves’ disease

Answer 11

Anti TSH receptor

Question 12

Hashimoto’s thyroiditis

Answer 12

Anti thyroglobulin

Anti thyroperoxidase

Question 13

CREST or limited cutaneous scleroderma

Answer 13

Anti centromere

Question 14

Microscopic polyangitis

Answer 14

P-ANCA

Question 15

Mixed connective tissue disease

Answer 15

Anti U1RNP

Question 16

Myasthenia gravis

Answer 16

Anti ach receptor

Question 17

Pernicious anaemia

Answer 17

Anti gastric parietal cells

Anti intrinsic factor

Question 18

Polymyositis

Answer 18

Anti Jo 1

Question 19

Primary biliary cirrhosis

Answer 19

Anti mitochondrial

Question 20

Rheumatoid arthritis

Answer 20

anti CCP

anti rheumatoid factor

Question 21

Sjögren’s syndrome

Answer 21

Anti ro
Anti la
Rheumatoid factor

Question 22

SLE

Answer 22

anti dsDNA+ histones
Anti ro
Anti la
Anti SM
Anti U1RNP

Question 23

T1DM

Answer 23

Anti glutamate decarboxylase

Anti pancreatic Beta cells

Question 24

Wegeners granulomatosis

Answer 24

c-ANCA

Question 25

Target of p ANCA

Answer 25

Myeloperoxidase

Question 26

Target of p anca

Answer 26

Myeloperoxidase

Question 27

Target of c anca

Answer 27

Proteinase 3

Question 28

Congenital heart block in SLE

Answer 28

Anti ro