Autoantibodies Flashcards
(22 cards)
Anti Ro, Anti La
Sjogren’s Syndrome
Rheumatoid Factor (RhF)
100%: Sjogren’s syndrome, Felty’s syndrome
70% RA
Mixed connective tissue disease, SLE, Systemic sclerosis
Anti CCP (anticyclic citrullinated peptide Ab)
Rheumatoid arthritis (96%)
ANA (Anti nuclear antibody)
> 95% SLE
75% Autoimmune hepatitis
Sjogren’s, Systemic sclerosis, RA
Anti-double stranded DNA (dsDNA)
SLE (60%)
Anti phospholipid Ab
Anti cardiolipin
Anti topoisomerase
Anti-phospholipid syndrome
Anti centromere Ab
Limited systemic sclerosis
CREST syndrome
Anti Jo-1 and Anti Mi-2
Polymyositis and dermatomyositis
Diffuse systemic sclerosis is associated with what Ab?
Anti-Scl-70
Anti Smooth muscle antibody is associated with? (Rheumatological and GIT)
SLE -20-30%
Autoimmune hepatitis 70%
PBC 50%
Idiopathic cirrhosis
Anti mitochondrial DNA is associated with what 3 GIT conditions?
Primary biliary cirrhosis >95%
Autoimmune hepatitis 30%
Idiopathic cirrhosis 25-30%
Gastro parietal cell Ab : associated with ?
Pernicious anaemia : >90%
Atrophic gastritis 40%
Normal 10%
Alpha- gliadin Ab
Anti tissue transglutaminase
Anti endomyseal Ab
Coeliac disease
Three antibodies associated with coeliac disease :
Alpha- gliadin Ab
Anti tissue transglutaminase
Anti endomyseal Ab
Thyroid peroxidase Ab associated with
Hashimoto’s thyroiditis 88%
Grave’s>50%
Other thyroid conditions:
Islet cell Ab and glutamic acid decarboxylase Ab : DMT1
Goodpasture’s disease is associated with
Glomerular basement membrane Ab
Cytoplasmic Antineutrophil cytoplasmic Ab (C-ANCA) is associated with what three conditions?
Granulomatosis with polyangiitis (Wegener's) 90% Microscopic polyangiitis (30%) Polyarteritis nodosa (10%)
Peri nuclear Antineutrophil cytoplasmic Ab (p-ANCA) is associated with what three conditions?
Churg - Strauss Pulmonary vasculatides (Goodpasture's) Microscopic polyangiitis (45%)
Can also be +ve in PSC, UC Crohn’s, autoimmune hepatitis, RA, SLE
ACh receptor Ab
Myasthenia gravis
Anti voltage gated Ca channel Ab:
Lambert-Eaton syndrome
Anti voltage gated K channel Ab: limbic encephalopathy
Anti Sm
Specific for lupus
Anti TIF -1 Gamma Ab
High suspicion of Malignancy in dermatomyositis if this Ab present
