Autoantibodies

Question 1

anti-ACh receptor

Answer 1

myasthenia gravis

Question 2

anti-GBM

Answer 2

Goodpasture syndrome

Question 3

anti-B2 microglobulin

Answer 3

anti-PL syndrome

Question 4

anticardiolipin

Answer 4

SLE, anti-PL syndrome

Question 5

lupus anticoagulant

Answer 5

SLE, anti-PL syndrome

Question 6

anticentromere

Answer 6

CREST (limited scleroderma)

Question 7

anti-desmoglein

Answer 7

pemphigus vulgaris

Question 8

anti-glutamic acid decarboxylase

Answer 8

DM1

Question 9

islet cell cytoplasmic antibodies

Answer 9

DM1

Question 10

anti-hemidesmosome

Answer 10

bullous pemphigoid

Question 11

anti-Jo-1 is against ___ and is found in _____

Answer 11

histidyl tRNA synthetase, polymiositis/dermatomycositis

Question 12

anti-Mi-2 is against _____ and is found in _____

Answer 12

helicase, polymyositis/dermatomyositis

Question 13

anti-SRP

Answer 13

polymyositis, dermatomyositis

Question 14

anti-microsomal

Answer 14

Hashimoto thyroiditis

Question 15

anti-thyroglobulin

Answer 15

Hashimoto

Question 16

anti-TPO

Answer 16

Hashimoto

Question 17

antimitochondrial

Answer 17

PBC, PSC

Question 18

anti-parietal cell

Answer 18

pernicious anemia

Question 19

anti-IF

Answer 19

pernicious anemia

Question 20

anti-PLA2 receptor

Answer 20

primary membranous nephropathy

Question 21

anti-Scl-70 is against _____ and is found in ______

Answer 21

DNA topoisomerase I, diffuse scleroderma

Question 22

anti-smooth muscle

Answer 22

autoimmune hepatitis

Question 23

anti-SSA (Ro), anti-SSB (La)

Answer 23

Sjogren

Question 24

anti-TSH receptor

Answer 24

Graves

Question 25

anti-presynaptic VG Ca+ channel

Answer 25

Lambert-Eaton

Question 26

anti-endomysial

Answer 26

celiac

Question 27

anti-tissue transglutaminase

Answer 27

celiac

Question 28

pANCA (mpo-ANCA)

Answer 28

microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Straus), UC

Question 29

cANA (pr3-ANCA)

Answer 29

granulomatosis with polyangiitis (Wegener)

Question 30

RF is against ____ and is found in _____

Answer 30

Fc portion of IgG, RA

Question 31

anti-CCP

Answer 31

RA

Question 32

ANA

Answer 32

SLE

Question 33

anti-dsDNA

Answer 33

SLE

Question 34

anti-Smith against ___ found in _____

Answer 34

snRNPs, SLE

Question 35

anti-histone

Answer 35

drug induced SLE (procainamide, dapsone, hydral, INH - slow acetylators)

Question 36

anti-RNP

Answer 36

mixed connective tissue dz