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Immuno > Autoantibodies > Flashcards

Autoantibodies Flashcards

(25 cards)

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1
Q

anti-cardiolipin,
anti-b2 glycoprotein 1a,
lupus anticoagulant

A

Antiphospholipid syndrome

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2
Q

anti-smooth muscle ab
anti-Liver Kidney microsomal 1 (LKM1)
anti-soluble liver antigen (SLA)

A

AI hepatitis

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3
Q

anti-Rh blood group ab

A

AIHA

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4
Q

anti glp IIb/IIIa

A

autoimmune thrombocytopenia purpura

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5
Q

p-ANCA staining for myeloperoxidase

A

eGPA - Churg Strauss. Remember Rx = PA’n’C - pred, aza and cyclophosphamide

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6
Q

anti-ttG IgA abs

anti-EMA IgA abs

A

Coeliac

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7
Q

anti-EMA abs

A

Dermatitis Herpetiformis (a/w CD)

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8
Q

anti-Ro

A

congenital heart block in babies of mothers with SLE

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9
Q

anti-Jo (tRNA synthetase)

A

Dermatomyositis (JohnaThan)

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10
Q

topoisomerase/scl70,
RNA Pol I/II/III
Fibrillarin

A

Diffuse Cutaneous Systemic Scleroderma
scl70 = SCLeroderma
fibrillarin = widespread skin

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11
Q

anti GBM

A

Goodpastures

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12
Q

anti TSHR

A

Grave’s

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13
Q

thyroglobulin abs

thyroperoxidase abs

A

Hashimotos

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14
Q

anti-centromere abs

A

Limited cutaneous systemic scleroderma

C = crest

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15
Q

p-ANCA

A

microscopic polyangiitis (MPA)

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16
Q

anti-U1RNP (speckled pattern)

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A

Mixed connective tissue disease

17
Q

anti AChR abs

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A

Myasthenia Gravis

18
Q

anti-IF abs (50%)

anti gastric parietal cell abs (90%)

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A

Pernicious anaemia

19
Q

anti SRP

20
Q

ant-GAD

21
Q

anti-Ro and La (speckled) +/- RF (70%)

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A

Sjogrens - sho ro la

22
Q

anti-mitochondrial ab

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A

primary biliary cirrhosis

23
Q

anti-CCP (95%), RF +ve (60-70%)

24
Q

anti dsDNA
anti histones
anti Ro, La and Sm
anti U1RNP (speckled)

25
c-ANCA with specificity for proteinase 3
Wegeners (GPA) - c is the 3rd letter of the alphabet (proteinase 3) Rx: CCC - corticosteroids, cyclophophamide, co-trimoxazole

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