Autoantibodies

Question 1

Adrenal failure -Autoimmune

Answer 1

Adrenal cortex

Sensitivity 60-90%

Question 2

Coeliac disease

Answer 2

GET

Gliadin

Endomysium (IgA)
Sensitivity 70-90%
Specificity High

TTG (IgA) anti-transglutaminase antibodies
Sensitivity 70-90%
Specificity High

Question 3

Dressler’s syndrome

Answer 3

Cardiac muscle

Question 4

Goodpasture’s syndrome

Answer 4

Glomerular BM
Sensitivity High
Specificity High

Question 5

Grave’s disease (pregnant)

Answer 5

TSH receptor

Question 6

Haemolytic anaemia-Autoimmune

Answer 6

Rhesus antigen

Question 7

Hepatitis-Autoimmune

Answer 7

Smooth muscle
Sensitivity 70%
Specificity Low

LKM (liver kidney microsomal antibodies)
Sensitivity Low
Specificity High

Question 8

Insulin dependent diabetes mellitus

Answer 8

Islet cells (early)
Sensitivity 90%
Specificity High

GAD (glutamic acid decarboxylase)
Sensitivity Varies
Specificity High

Question 9

Microscopic polyangiitis (MPA)

Answer 9

pANCA
Sensitivity 50%
Specificity Low

Question 10

Myasthenia gravis

Answer 10

Acetylcholine receptor
Sensitivity 80-90%
Specificity High

MUSK

Question 11

Ovarian failure-Autoimmune

Answer 11

Ovary

Question 12

Parathyroid failure-Autoimmune

Answer 12

Parathyroid

Sensitivity 10%

Question 13

Pemphigoid

Answer 13

Skin BM

Sensitivity 90%

Question 14

Pemphigus

Answer 14

Desmosomes
Sensitivity 70%

Desmoglein 3

Question 15

Peripheral neuropathy

Answer 15

Ganglioside (GM1)

Question 16

Pernicious anaemia

Answer 16

Parietal cell
Sensitivity 90%
Specificity Low

Intrinsic factor
Sensitivity 66%
Specificity High

Question 17

Polymyositis/Dermatomyositis

Answer 17

ANA (Antinuclear Antibodies )
Sensitivity 40-70%
Specificity Low

Jo-1
Sensitivity 20%
Specificity High

Jo 1 (histidyl tRNA synthetase) is a member of the amino acyl-tRNA synthetase family of enzymes found in all nucleated cells.

Question 18

Primary biliary cirrhosis

Answer 18

Mitochondria
Sensitivity 100%
Specificity High

Question 19

Rheumatoid arthritis

Answer 19

Rheumatoid factor
Sensitivity 70%
Specificity Low

Anti-cyclic citrullinated peptide (anti-CCP)

Question 20

Sjogren’s syndrome

Answer 20

ANA
Sensitivity 40-70%
Specificity Low

Ro and La
Sensitivity 40-70%
Specificity Low

Question 21

Systemic lupus erythematosus

Answer 21

ANA
Sensitivity >99%
Specificity Low

dsDNA
Sensitivity 70-90%
Specificity High

Sm
Sensitivity 30%
Specificity High

Question 22

Systemic sclerosis-diffuse

Answer 22

ANA
Sensitivity 60-90%
Specificity Low

Scl-70
Sensitivity 20%
Specificity High

Question 23

Systemic sclerosis-limited

Answer 23

ANA
Sensitivity 60-90%
Specificity Low

Centromere

Question 24

Thrombocytopenia-Autoimmune

Answer 24

GpIIb/IIIa

Question 25

Thrombosis/ miscarriage

Answer 25

Phospholipid Specificity low Cardiolipid

Question 26

Thyroiditis- Autoimmune/Hashimoto's

Answer 26

Thyroid peroxidase Sensitivity High Specificity Low Antimicrosomal antithyroglobulin anti-thyroid pyroxidase

Question 27

Granulomatosis with polyangiitis | GPA, Wegener’s Granulomatosis

Answer 27

cANCA (Cytoplasmic antineutrophil cytoplasmic antibodies) Sensitivity High Specificity Moderate

Question 28

Specificity

Answer 28

Measures the proportion of negatives that are correctly identified as such = True negatives/ All test negatives

Question 29

Sensitivity

Answer 29

The proportion of true positives picked up by the test = True positives/ All test positives

Question 30

MHC II DR2 only

Answer 30

Goodpasture syndrome Hayfever MS

Question 31

MHC II DR3 only

Answer 31

Graves

Question 32

MHC II DR2 DR3

Answer 32

SLE

Question 33

MHC II DR3 DR4

Answer 33

DM1

Question 34

MHC II DR3 DR5

Answer 34

Hashimoto thyroiditis

Question 35

MHC II DR4 only

Answer 35

Rheumatoid arthritis

Question 36

MHC I A3 only

Answer 36

Hemochromatosis

Question 37

MHC II DQ2/DQ8

Answer 37

Celiac disease

Question 38

Anti-beta2 glycoprotein

Answer 38

Antiphospholipid syndrome

Question 39

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 39

Polymyosiitis, dermatomyosiitis

Question 40

B27

Answer 40

Reactive arthritis IBD arthritis Psoriatic arthritis Ankylosing spondylitis

Question 41

MHC II DR5 only

Answer 41

Pernicious anaemia