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RACP 2022 Written > AutoAntibodies - From String of Pearls > Flashcards

AutoAntibodies - From String of Pearls Flashcards

1
Q

Anti-Ro (SSa)

A

Target: Ribonucleoproteins
Disease: SLE, Neonatal heart block + Primary Sjogrens syndrome

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2
Q

Anti-La (SS-B)

A

Against: Ribonucleoproteins
Disease: Primary Sjogrens

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3
Q

Anti-centromere Ab

A

Against: Centromere ANA pattern
Disease: CREST syndrome and limited Scleroderma

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4
Q

Anti- dsDNA

A

Against - double stranded DNA
Disease: SLE

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5
Q

Anti Jo1

A

Against - Histidine tRNA ligase
Disease: Inflam myopathy aka anti syntheses syndrome - polymyositis

mech hands. Anti-Jo + ILD = polymyositis

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6
Q

Anti-U1-RNP

A

Against: Ribonucleoprotein
Disease - Mixed Connective Tissue Disease

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7
Q

Anti- Smith

A

Target: snRNP core proteins
Disease: SLE (CNS lupus + Renal LUpus, African population , poor prognosis)

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8
Q

Anti- topoisomerase (anti-Scl70)

A

Target: Type 1 Topoisomerase
Disease: Systemic Sclerosis (diffuse)

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9
Q

Anti-histone

A

Taret: histones
SLE and drug induced lupus

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10
Q

Anti -CCP

A

Target: Cyclic citrullinated peptide
D: RA

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11
Q

Rheumatoid Factor

A

Target: IgG
D: RA

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12
Q

Anti-thrombin

A

Target: thrombin
D: SLE

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13
Q

c-ANCA (PR3)

A

T - Anti-proteins in neutrophil cytoplasm
D - GPA - Granulomatosis with polyangiitis aka wegners

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14
Q

p-ANCA (MPO)

A

T- anti-neutrophil perinuclear
D - MPA Microscopic polyangiitis, eGPA Eosinophilic granulomatosis with polyangiitis aka Churg-Strauss, Systemic vasculitides

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15
Q

Anti-SRP

A

T- Signal recogintion particle
D- Polymyositis (highly agressive form, poorly response immunosupression)

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16
Q

Anti-RNA polymerase III

A

T - RNA polymerase II
D - Renal crisis in systemic sclerosis

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17
Q

Anti-Ro52

A

second most common ab for systemic scleroderma fter anti-SCL70.
ILD and dermtomyositis

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18
Q

Anti-p155

A

Dermatomyositis subset - assoc with malignancy and more severe cutaneous involvement

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19
Q

Anti-HMGCR

A

T - HMG-CoA reductase
D - Statin induced necrotising myositis (immunosupress)

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20
Q

BAFF + IL-6

A

D - GCA, PMR

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21
Q

Anti-tTG

A

T - Transglutaminases
D - Coeliac disease

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22
Q

Anti-eTG

A

D - Dermatitis herpetiformis

Assoc with Coeliac Disease. Chronic, very itchy skin rash made up of bumps and blisters.
The exact cause of dermatitis herpetiformis isn’t known. Genetics, gluten sensitivity and disorders in which the immune system attacks healthy cells (auto-immune disorders) may play a role.
The main symptom is an off-and-on skin rash.
Antibiotics and a gluten-free diet are treatments.

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23
Q

Anti-Actin

A

Coeliac disease

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24
Q

Anti- LKM-1

A

D - Autoimmune hepatitis
most frequent young women and girls - poor prognosis

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25
Q

Anti-SMA (smooth muscle)

A

T - Smooth muscle
D - chronic autoimmune hepatitis

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26
Q

AMA (anti-mitochondrial antibody)

A

T - Mitochondria
D - Primary billary cirrhosis

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27
Q

ASCA

A

T - Anti-Saccharomyces cerevisiae antibody
D - Crohn’s Disease (helps diff from UC - pANCA for UC)

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28
Q

Anti-ganglioside GQ1B

A

T - Ganglioside
D - Miller Fisher Syndrome

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29
Q

Anti-ganglioside GD3

A

T- ganglioside
D - Acute motor axonal neuropathy

30
Q

Anti-ganglioside GM1

A

T- ganglioside
D - Multifocal motor neuropathy with conduction block

31
Q

Anti-AChR (Nicotinic acetylcholine receptor)

A

Disease - Myasthenia Gravis

32
Q

Anti- MUSK *muscle specific kinase

A

Myasthenia gravis - not seen in ocular variant

33
Q

Anti - LRP4 (lipoprotein receptor - related protein)

A

Myasthenia gravis (mild/mod)

34
Q

Anit-VGCC - voltage gated calcium channel p/1 type

A

D - Lambert Eaton Myasthenic syndrome

35
Q

Anti-Hu (ANNA-1)

A

T- Neuronal nuclear proteins
D - SCLC, Neuroblastmoas, Paraneoplastic cerebellar degeneration, limbic encephalitis, encephalomyelitis, subacute senory neuronopathy, choreathetosis, myoclonus

36
Q

Anti-Yo

A

T- Cerebellar Purkinje cells
D - Ovarian and breast ca, paraneoplastic cerebellar degeneration

37
Q

Anti-Ma

A

Encephalomyeleits, limbic encephalitis

38
Q

ANti-RI (ANNA-2)

A

T - Neuronal nuclear proteins
D - Opsoclonus myoclonus syndrome

39
Q

Anti-Tr

A

T - GLuamate recpetor
paraneoplasic cerebellar syndrome

40
Q

Anti-amphiphysin

A

D - Stiff person syndrome, paraneoplastic cerebellar degeneration

41
Q

Anti-GAD

A

T - Glutamate decarboxylase
D - Breast, CRC, SCLC - stiff person syndrome

42
Q

Anti- VGKC

A

T - Voltage - gated potassium channel (VGKC)
D - Limbic encephalitis, Isaac’s Syndrome (autoimmune neuromyotonia)

43
Q

ANti-CRMP-5

A

T - Collapsin response mediator protein 5
D - Optic neuropathy, chorea

44
Q

Anti-NMDAr

A

T - N-methyl-D-aspartate receptor (NMDA)
D - Anti-NMDA receptor encephalitis

45
Q

Anti-NMO

A

T - Aquaporin-4
D - Neuromyelitis optica

46
Q

Anti-Cardiolipin

A

Antiphospholipid syndrome

47
Q

Antiphospholipid syndrome

A

ANti-cardiolipin, Anti-beta-2-glycoprotein-1, Anti PF4

48
Q

Anti-beta-2-glycoprotien 1

A

Antiphospholipid syndrome

49
Q

Anti- PF 4

A

Heparin induced thrombocytopenia

50
Q

Anti-TPO

A

T - Thyroid peroxidase (microsomal)
D - Hashimoto’s thyroiditis + Graves disease

51
Q

Anti-TgAbs

A

T - Thyroglobuin
D - Hashimoto’s Thyroiditis

52
Q

Anti-TRABs

A

T- TSH receptor
D - Graves disease

53
Q

Anti-GAD

A

T - Glutamate decarboxylase
D - T1DM

54
Q

Anti-PLA2R

A

T - Podocyte membrane antigen
D - Membranous GN - 80% assoc primary - good response to rituximab

55
Q

Anti-THSD7A

A

Membranous GN 2-5%

56
Q

suPAR

A

T - Soluble urokinase type plasminogen activator receptor
D- FSGS

57
Q

Anti-GBM

A

T - alpha-3 subunit of type IV collagen
D - Goodpasture’s

58
Q

C904G72 disease association?

A

FTD-MND

59
Q

ALpha synuclein

A

Parkinsons, MSA, DLB

60
Q

Tauopathies

A

Alzheimers, PSP, CBS, FTDP

61
Q

TARDBP gene

A

FTD

62
Q

Differentiating test Scleroderma?

A

+ anti-centromere Ab for limited scleroderma
+ anti-Scl 70 or anti-top for diffuse

63
Q

Differentiating test Mixed connective tissue disease?

A

Positive anti-RNP Ab

64
Q

Differentiating test Drug induced lupus?

A

Positive anti-histone ab

65
Q

Differentiating test Adult Still’s disease?

A

Elevated ferritin in a patient presenting with fever, rash and sero NEG polyarthritis

66
Q

Differentiating test Septic arthritis?

A

Joint aspiration or synovial biopsy yields positive culture >50,000

67
Q

Differentiating test Sjogren’s syndrome?

A

Positive anti-Ro (heart block + lupus) and anti-La

68
Q

Differentiating test SLE

A

Positive ANA (most sensitive)
Anti-dsDNA and anti-Smith Ab (spec)

69
Q

Differentiating test RA

A

Anti- CCP

70
Q

Differentiating test Psoriatic arthritis

A

Pencil in cup deformity on XRAY (adv disease)

71
Q

Differentiating test Gout?

A

Synovial fluid Ex - strong neg birefingent, needle shaped crystals under polarised light

72
Q

Auto-Antibodie in ITP?

A

ANti-GLycoprotien IIB-IIa

RACP 2022 Written (21 decks)

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