Autoimmune Diseases Flashcards
(7 cards)
1
Q
Goodpastures Disease
A
Type II
autoantibodies against type IV collagen of basement in glomerulus and alveoli
Glomerular nephritis (blood urine, decreased urine output)
Alveolar hemorrhages (bloody sputum/cough)
linear-smooth distribution of antibody upon staining
2
Q
Myasthenia Gravis
A
Type II Autoantibodies bind to AchR in NMJ predominantly women muscle weakness Thymic hyperplasia* Thymoma* complement activation causes injury
3
Q
Graves Disease
A
Type II Autoantibody that mimics TSH Th2 mediated low TSH, high T3/T4 Goiter Hyperthroidism Exophthalmos (protruding eyes) predominantly women
4
Q
Hashimoto Thyroiditis
A
Type II and type IV
Autoantibodies that block uptake of Iodine
Autoreactive CD4 T cells release TNFalpha
Th1 disease
mononuclear cellular infiltration of thyroid
Hypothyroidism
Thyroid distruction
5
Q
Scleroderma
A
Type II and IV (but systemic) T cell involvement: pro-fibrotic cytokines Autoantibodies: Topoisomerase I, Centromeres small vessel obliterative disease systemic fibrosis Raynauds Phenomenon Nucleoli staining CREST
6
Q
Systemic Lupus Erythematosus (SLE)
A
Type III- Immune complex Autoantibodies against dsDNA and Smith (RNA-protein complex) women, African Americans Malar Rash Photosensitivity Arthritis, Nephritis Whole Nucleus staining Globular staining of glomerulus
7
Q
Rheumatic Arthritis
A
Type IV damage Synovial Pannus Rheumatic Factor Anti-CCP HLA-DR4 Rheumatic Nodules Distorted joints
