Autoimmune Not On Brainscape Flashcards
How does autoimmunity occur
Breakdown of central tolerance
- failure to delete auto reactive t or B cells
Breakdown of peripheral tolerance
- regulatory T cell deficits
- impaired immunomodulation
- altered self antigens
Activation of auto reactive B cells
- T cell independent activation
- carrier effect
Hashimotis self antigen
Thyroid peroxidase and thyroglobulin
T1DM self antigen
Proteins in pancreatic island cell
Multiple sclerosis self antigen
Myelin sheath
Goodpastures self antigen
GMB
Addisons self antigen
Steroid 21 hydroxylase in adrenal cortex
Graves self antigen
TSH receptor
MG self antigen
ACH receptor
Pernicious anaemia self antigen
Intrinsic factor and parietal cells
Autoimmune haemolytic anaemia self antigen
RBC antigens
RA self antigen
Rheumatoid factor- Fc portion of IgG
SLE self antigen
Ds DNA plus histones
Sjorgens syndrome self antigen
Nuclear antigens- Ro and La
Autoimmune diseases that are type IV hypersensitivity
- hashimotos
- T1DM
- multiple sclerosis
- addisons
- RA
- sjorgens syndrome
Autoimmune diseases that are type II hypersensitivity
Good pastures Graves MG Pernicious anaemia Autoimmune haemolytic anemia
Autoimmune diseases that are type III hypersensitivity
RA
SLE
What does sjorgens syndrome cause
Dry eyes, mouth and arthritis
Antibody in lambert Eaton myasthenia syndrome
Anti voltage gated Ca2+ channel
What is the significance of primary autoantibodies
- drive disease
- if removed via plasmapheresis then symptoms are alleviated
Which diseases tested for by immune fluorescence
T1DM goodpastures Addisons Pernicious anaemia SLE
How test for Hashimotos MG HDN/autoimmune haemolytic anaemia SLE RA
Hashimotos - infiltration T cells MG- radioimmunoassay HDN/autoimmune haemolytic anaemia - coombs SLE- radioimmunoassay RA- agglutination
What bacteria and antigen can cause rheumatic fever
- steptococcus pyogenes m protein
- antigen in cardiac muscle
What bacteria and antigen can cause guillian barre
- campylobacter jejuni glycoproteins
- myelin associated gangliosides
What bacteria and antigen can cause T1DM
Coxasakieviruse B4 nuclear protein
Pancreatic island cell
