Autoimmune Serology Flashcards
(32 cards)
non extractable nuclear antigens
ds-DNA
Histone
Nuclear RNA
Extractable nuclear antigens
SM RNP Ro (SSA) La (SSB) Scl-70 (topoisomerase I) Jo-1
What does the ANA titer represent
the last doubling dilution in order to produce a sample with no fluorescence
homogenous/diffuse nuclear fluorescence ANA pattern
anfi-dsDNA (SLE)
peripheral (rim) nuclear fluorescence ANA pattern
anti-dsDNA (SLE)
speckled nuclear fluorescence ANA pattern
anti-U1 RNP
anti-Ro and La
= MCTD, Sjogren
centromeric nuclear fluorescence ANA pattern
kinetochore (CREST)
nucleolar nuclear fluorescence ANA pattern
antifibrillarin (SSc)
what % of pop has + ANA, how does age affect chance of + ANA?
5%, increases + with age (15% of pts > 55 yo have elevated ANA titer with no clinical significance)
Ab a/w lupus nephritis
anti-dsDNA, anti-Sm, anti-C1q
Ab a/w neuropsychiatric LE
anti-rRNP
Ab a/w photosensitvity
anti-Ro and La
Ab a/w neonatal lupus/congenital heart block
anti-Ro and La
Ab a/w drug induced LE
anti-histone
Ab a/w SLE with polymyositis
anti-Ku (p70/80 nucleolar protein)
Ab a/w possible risk of SLE in DLE pts
anti-ssDNA (denatured DNA)
Ab a/w SCLE, mild SLE with limited systemic involvment
anti-U1RNP
Abs a/w Sjogren
anti-alpha-fodrin, Ro, La
Ab in Sjogren a/w inc risk of lymphoma and systemic dz
anti-Ro
Ab a/w rapid onset of SS with severe disease and diffuse cutaneous involvement
anti-RNA polymerase
Ab a/w pulm HTN in SS
anti-fibrullarian (U3RNP)
Ab a/w CREST syndrome
anti-centromere
Ab a/w p70/p80 nucleolar protein
anti-Ku (SS)
Ab a/w diffuse skin disease in SS and interstitial lung dz
anti-scl-70
