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Autoimmunity Flashcards

(3 cards)

1
Q

Goodpasture’s Syndrome

Primary Pathology initiated by, Antigen, Antibodies, Characteristic features, Investigations, Mechanism of Pathology

A
  • Primary Pathology: Antibody to cell surface antigen
  • Antogen: Glomerular Basement Membrane (GBM)
  • Antibodies: Anti-GBM antibody
  • Characterirst features: Lung (Alveloar) & Kidney
    Linear deposition of IgG & Complement
  • Inverstigation: Anti-GBM antibodies
  • Mechanism of Pathology: Pathology manifests as Type II hypersensitivity immune responses
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2
Q

Cold Agglutinin Disease

Primary Pathology initiated by, Antigen, Antibodies, Characteristic features, Investigations

Mechanism of Pathology

A
  • Primary Pathology Initiated: Antibody to cell surface antigen
  • Antigien: Glycophorin (Ii)
  • Antibodies: Anti-glycophorin Ab (Anti-Ii antibody)
  • Chracterisitc features: Anemia
  • Investigation: Agglutination on blood smear
  • Mechanism of P: Complement fixation – IgM antibodies.
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3
Q

Pernicious Anemia

Primary Pathology initiated by

Antigen

Antibodies

Characteristic features

Investigations

Mechanism of Pathology

A
  • PPI: Antibody to cell surface antigen
  • Antigen:Gastric parietal cell antigen H+/K+ ATPase
  • Antibodies: Anti-parietal cell H+/K+ ATPase Ab.
  • Chracteristic features: Defective red blood cells: megablastic anemia

Serum B12

Destruction of parietal cells that secrete intrinsic factor

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