Autoimmunity Flashcards

1
Q

What are seropositive conditions?

A

Conditions that produce auto-antibodies

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2
Q

What are the factors that contribute to the loss of regulation of auto-antibodies?

A

genetic predisposition and several environmental insults such as infection or prolonged chemical exposure

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3
Q

What is the associated condition with the antibody Anti-CCP ?

A

Rheumatoid arthritis

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4
Q

What is the associated condition with the antibody anti-nuclear antibody (ANA)?

A

SLE, Sjogren’s syndrome, Systemic Sclerosis, MCTD, autoimmune liver disease

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5
Q

What is the associated condition with the antibody anti-double stranded DNA antibody (dsDNA)?

A

SLE

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6
Q

What is the associated condition with the antibody anti-Sm?

A

SLE

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7
Q

What is the associated condition with the antibody Anti-Ro?

A

SLE, Sjogren’s syndrome

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8
Q

What is the associated condition with the antibody Anti-La?

A

Sjogren’s syndrome

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9
Q

What is the associated condition with the antibody Anti-centromere?

A

Systemic sclerosis

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10
Q

What is the associated condition with the antibody anti-Scl-70?

A

systemic sclerosis

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11
Q

What is the associated condition with the antibody anti-RNP antibody?

A

SLE, mixed connective tissue disease

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12
Q

What is the associated condition with the antibody anti-Jo-1?

A

myositis

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13
Q

What is the associated condition with the antibody anti-cardiolipin and lupus anti-coagulant?

A

anti-phospholipid syndrome

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14
Q

What is the associated condition with the antibody anti-neutrophil cytoplasmic (ANCA)?

A

small vessel vasculitis (GPA, EGPA, MPA)

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