autoimmunity and the gut Flashcards
(35 cards)
Factors affec
– Prematurebirth
– Caesarean sec
Caesarean sec
Staphylococcus,Corynebacterium,andPropionibacteriumspecies
Infants born vaginally were colonized mostly by bacterial communi
Lactobacillus, Prevotella, or Sneathiaspp,
Short-term consumption of diets composed entirely of _____ or ____ products alters microbial community structure and overwhelms inter- individual differences in microbial gene expression
animals
plant
Going from a low fat, plant polysaccharide rich diet to a high fat, high sugar Western diet changed the microbiota in ___ day in GF mice
one
Our results link non-caloric sweetener consump?on with dysbiosis and metabolic _____
abnormalities.
Modulation of the gut microbiome by alteration of food habits has potential for disease prevention. Dietary polyphenols naturally occurring in ____ and ____… are extensively metabolized by gut bacteria into end-products that support a significant effect on the functional ecology of symbiotic partners that can affect the host physiology.
coffee
cocoa
Diet-associated changes in the intestinal microbiome as a crucial factor regulating inflammasome- and caspase-8-mediated maturation of IL-1β and _____
osteomyelitis
Gut also has the largest collection of immune cells, consisting of 70% of all _______ _____ in the body
lymphoid tissues
The greatest number of bacteria is in the large intestine. The majority of these bacteria, approximately ___%, cannot be cultivated by current laboratory microbiological methods
70%
Number of genes of our intestinal microbiota ____X greater than the number of genes in the human genome!
150x
opens spaces between the cells of the intes
zonulin
If leaky gut present, the spaces between cells allow larger protein molecules to get into the bloodstream where an immunologic reaction can take place.
Body is then primed to react to those proteins when they appear leading to immune response, inflammation and___ activation
LPS
Common Causes of
Increased Intestinal Permeability
- Inflammatory Bowel disease
- NSAID therapy
- Small Intestinal Bacterial Overgrowth (SIBO)
- Celiac disease
- Protozoal infections
- Food allergy
- Chronic Alcoholism
- Diarrhea
- Strenuous exercise
- Increasing age
- Nutritional Depletions
Triggers for Autoimmunity
Gene
Genetic predisposition accounts for approximately ___% of all autoimmune diseases. The rest are due to environmental factors, including toxic chemicals, dietary components, gut dysbiosis, and infections
30%
Environmental Triggers for Autoimmunity
Chemical toxicants Heavy metals Infectious agents through molecular mimicry Emotional stress Drugs
Chemical toxicants
– Aluminum hydroxide as adjuvant in vaccine (autoimmune hepa
Several studies have demonstrated the involvement of autoimmune responses in _____ disease. Evidences of involvement of immunopathology have been reported in periodontal disease. Bacteria in the dental plaque may induce antibody formation
periodontal
Diet Induced Autoimmunity
Pesticides Artificial sweeteners High processed salt consumption plasticizers antibiotics proton pump inhibitors histamine 2 blockers
bind to protein in foods altering so immune system attacks
Pesticides
leading to cardiovascular
disorders and contributing to immune reactions
High processed salt consumption
such as bisphenol A in food and beverage containers contributes to this overreaching environmental exposure to xenobiotics as well.
plasticizers
Vitamin ___ deficiency has been epidemiologically correlated with a higher risk for autoimmune diseases
D
