AUTOINFLAMMATORY DISORDERS Flashcards
1
Q
What are the autoinflammatory disorders?
A
Disorders in which we have an activation of the inflammation without an apparent inflammatory stimulus. They are diseases very difficult to be classified but all of them are characterized by an hyper-production of IL-1.
2
Q
Inflammasome
A
Multimeric complex
Subunits
How it is activated (pathogen-derived activation/endogenous activation)
3
Q
How can we release IL-1?
A
Gasdermin-D
4
Q
Hereditary syndromes with periodic fever
A
Familiar mediterranean fever
Hyper-IgD with periodic fever syndrome
CAPS
TRAPS
5
Q
Target therapy against IL-1
A
Anakirna
Rilonacept
Canakizumab
