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Pharmacology 514 > Autonomic Drugs > Flashcards

Autonomic Drugs Flashcards

1
Q

For sympathetic sweat glands, what is the neurotransmitter on the preganglionic neuron?

A

Ach

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2
Q

For sympathetic sweat glands, what is the receptor at the preganglionic neuron?

A

nAChR

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3
Q

For the sympathetic sweat gland, what is the receptor at the postganglionic neuron?

A

mAchR

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4
Q

For the sympathetic sweat gland, what is the neurotransmitter at the postganglionic neuron?

A

Ach

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5
Q

For parasympathetic stimulation, what is the receptor on the preganglionic neuron?

A

nAchR

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6
Q

What is the neurotransmitter of parasympathetic stimulation at the preganglionic neuron?

A

Ach

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7
Q

What is the neurotransmitter for parasympathetic stimulation at the postganglionic neuron?

A

Ach

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8
Q

What is the receptor for parasympathetic stimulation on the postganglionic neuron?

A

mAchR

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9
Q

For sympathetic stimulation, what is the receptor on the preganglionic neuron?

A

nAchR

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10
Q

For sympathetic stimulation, what is the neurotransmitter on the preganglionic neuron?

A

Ach

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11
Q

For sympathetic stimulation, what is the neurotransmitter at the postganglionic neuron?

A

NE

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12
Q

For sympathetic stimulation, what are the receptors on the postganglionic neuron?

A

adrenergic receptors

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13
Q

Where do parasympathetic afferent neurons originate?

A

cranial nerves in brain and sacral area

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14
Q

Where is the origin for sympathetic neurons?

A

thoracic and lumbar areas

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15
Q

Describe the pre and post ganglia for sympathetic neurons?

A

short pre-ganglion, long post-ganglion

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16
Q

Describe the pre and post ganglia for parasympathetic neurons?

A

long pre-ganglion and short post-ganglion

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17
Q

Would a sympathetic response be diffuse or discrete?

A

Diffuse

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18
Q

Would a parasympathetic response by diffuse or discrete?

A

discrete

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19
Q

What type of receptor is a dopaminergic receptor?

A

GPCR; cAMP 2nd messenger

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20
Q

Where are the dopaminergic receptors?

A

D2 - in brain

D1 - blood vessels - renal and other splanchnic (limited in periphery)

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21
Q

What are NANC’s (non-adrenergic and non-cholinergic) function in PNS?

A 
Nitric oxide (NO)
Vasoactive intestinal peptide (VIP)
Calcitonin Gene Related Peptide (CGRP)
Neuropeptide Y (NPY)
Substance P
22
Q

What are the steps of neurotransmission?

A
  1. synthesis
  2. storage
  3. release (vesicle fuse with nerve terminal)
  4. action at receptor
  5. termination (reuptake, enzyme degradation, or diffusion)
23
Q

What type of receptors are alpha and beta?

A

GPCR

24
Q

What type of receptor is a nAChR?

A

ligand-gated ion channel

25
Q

What is the main difference between the two types of muscarinic receptors?

A

different 2nd messengers

26
Q

What is the primary way of Ach degradation?

A

breakdown with acetylcholinesterase to choline and acetate and choline is recycled

27
Q

What is the primary termination of action of NE?

A

reuptake

28
Q

What are the ligands for alpha and beta receptors?

A

NE and epi and sometimes dopamine

29
Q

What are the 2 major subtypes of nicotinic receptors?

A

NicN and NicM

30
Q

Where are nicotinic cholinergic receptors located?

A

autonomic ganglia, skeletal muscle innervated by somatic motor system, CNS

31
Q

What is the concentration of atropine?

A

0.4 mg/mL

32
Q

What is the dose of atropine?

A

0.02 mg/kg (15-70 mcg/kg)

33
Q

What is the onset of atropine?

A

15-30 seconds

34
Q

What is the peak of atropine?

A

2 mins

35
Q

What is the duration of atropine?

A

1-2 hours

36
Q

What is the concentration of glycopyrolate?

A

0.2 mg/mL

37
Q

What is the dose of glycopyrolate?

A

0.01 mg/kg (10-20 mcg/kg)

38
Q

What is the onset of glycopyrolate?

A

1 min

39
Q

What is the peak of glycopyrolate?

A

5 mins

40
Q

What is the duration of glycopyrolate?

A

2-4 hours

41
Q

What type of AChE is edrophonium?

A

quarternary ammonium anticholinesterase

42
Q

What is the concentration of edrophonium?

A

10 mg/mL

43
Q

What is the dose of edrophonium?

A

0.5-1 mg/kg

44
Q

What is the onset of edrophonium?

A

30-60 secs

45
Q

What is the peak of edrophonium?

A

1-5 mins

46
Q

What is the duration of edrophonium?

A

5-20 mins

47
Q

What type of drug is neostigime?

A

carbamyl ester anticholinesterase

48
Q

What is the concentration of neostigmine?

A

0.5 or 1 mg/mL

49
Q

What is the dose of neostigmine?

A

0.04-0.08 mg/kg

50
Q

What is the onset of neostigmine?

A

1-3 mins

51
Q

What is the peak of neostigmine?

A

5-7 mins

52
Q

What is the duration of neostigmine?

A

40-60 mins

Pharmacology 514 (7 decks)

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