Autonomic Drugs I

Question 1

adrenal medulla and sweat glands

Answer 1

sympathetic

-but innervated by cholinergic

Question 2

botulinum

Answer 2

prevent release of ACh at cholinergic terminals

Question 3

nAChR mechanism

Answer 3

ligand gated
-Na/K channels

Nn - autonomic ganglia
Nm - at NMJ

Question 4

NMJ receptor

Answer 4

nAChR

Question 5

adrenal medulla receptor

Answer 5

nAChR

Question 6

sweat gland receptor

Answer 6

mAChR - postganglionic - sympathetic

Question 7

parasympathetic receptors

Answer 7

nAChR - preganglionic

mAChR - postganglionic

Question 8

sympathetic to renal vasc smooth muscle receptors

Answer 8

pregang - nAChR

postgang - D1

Question 9

mAChR mechanism

Answer 9

GPCRs - act through 2nd messengers

5 subtypes - M1-M5

Question 10

sympathetic receptors

Answer 10

pregang - nAChR

postgang - alpha/beta adrenergic - NE

Question 11

all preganglionic

Answer 11

nAChR

Question 12

alpha1 receptor type

Answer 12

GPCR q

Question 13

alpha1 receptor function

Answer 13

vasc smooth m contraction
pupil dilator m contraction (mydriasis)
increased intestinal and bladder sphincter contraction

Question 14

alpha2 receptor type

Answer 14

GPCR i

Question 15

alpha2 receptor function

Answer 15

decreased sympathetic outflow
decreased insulin release
decreased lipolysis
increased platelet aggregation
decreased aqueous humor production

Question 16

beta1 receptor type

Answer 16

GPCR s

Question 17

beta1 receptor function

Answer 17

increased HR
increased contractility
increased renin release
increased lipolysis

Question 18

beta2 receptor type

Answer 18

GPCR s

Question 19

beta2 receptor function

Answer 19

vasodilation
bronchodilation
increased lipolysis
increased insulin release
decreased uterine tone (tocolysis)
ciliary muscle relaxation
increased aqueous humor production

Question 20

M1 receptor type

Answer 20

GPCR q

Question 21

M1 receptor function

Answer 21

CNS, enteric nervous system

Question 22

M2 receptor type

Answer 22

GPCR i

Question 23

M2 receptor function

Answer 23

decreased heart rate

contraction of atria

Question 24

M3 receptor type

Answer 24

GPCR q

Question 25

M3 receptor function

Answer 25

exocrine gland secretion - lacrimal, salivary, gastric acid increased gut peristalsis increased bladder contraction bronchoconstriction pupillary sphincter contraction - miosis ciliary muscle contraction - accomodation

Question 26

D1 receptor type

Answer 26

GPCR s

Question 27

D1 receptor function

Answer 27

relax renal vasc smooth m

Question 28

D2 receptor type

Answer 28

GPCR i

Question 29

D2 receptor function

Answer 29

modulate transmitter release - in brain

Question 30

H1 receptor type

Answer 30

GPCR q

Question 31

H1 receptor function

Answer 31

``` nasal and bronchial mucus production increased vasc permeability contraction bronchioles pruritis pain ```

Question 32

H2 receptor type

Answer 32

GPCR s

Question 33

H2 receptor function

Answer 33

increased gastric acid secretion

Question 34

V1 receptor type

Answer 34

GPCR q

Question 35

V1 receptor function

Answer 35

increased vasc smooth m contraction

Question 36

V2 receptor type

Answer 36

GPCR s

Question 37

V2 receptor function

Answer 37

increased H2O permeability CT of kidney

Question 38

GPCR q function

Answer 38

activate phospholipase C -cleave PIP2 > IP3 and DAG DAG > protein kinase C IP3 > increased Ca - smooth m contraction

Question 39

GPCR s function

Answer 39

activate adenylyl cyclase -ATP to cAMP cAMP - activate protein kinase A protein kinase A - increased Ca in heart inhibit myosin light chain kinase smooth m

Question 40

GPCR i function

Answer 40

inhibit adenylyl cyclase -less ATP to cAMP less protein kinase A less Ca in heart disinhibit myosin light chain kinase smooth m

Question 41

QISS and QIQ til you're SIQ of SQS

Answer 41

Q - alpha1 I - alpha2 S - beta1 S - beta2 Q - M1 I - M2 Q - M3 S - D1 I - D2 Q - H1 S - H2 Q - V1 S - V2