Autonomic Ganglia

Question 1

ganglionic nicotinic receptors

Answer 1

ion channels, pentamer

binding Ach opens ion channel (Na+ in, K+ out)

Question 2

nicotine

Answer 2

ganglionic stimulant
increase HR, BP, respiratory rate
Ach - acts on nicotinic and muscarinic receptors
insecticides often use as effective agent
CNS stimulant - convulsion, headaches
NMJ paralysis - depolarizing block (high doses)
hypertension, hypotension, vomiting, diarrhea

Question 3

ganglionic blocking agents

Answer 3

mecamylamine - oral, CNS effect.
trimethapan - not oral, hypertensive emergency, control hypotension in surgery, short duration.
toxicity - hypotension, PHT (treat with pressor agent).
last resort drugs

Question 4

treatment for ganglionic stimulants

Answer 4

muscarinic excess: anticholinergic (atropine)
NMJ blockade: mechanical respiration
CNS stimulation: anticonvulsant (diazepam)