Autonomic NS- Cholinergic

Question 1

Muscarinic receptors- Which GPCR?

Answer 1

M1- Gq
M2- Gi
M3- Gq
M4- Gi
M5- Gq

Question 2

Adrenergic receptors- Which GPCR?

Answer 2

a1- Gq
a2- Gi
B1- Gs
B2- Gs
B3- Gs

Question 3

M1 location

Answer 3

Nerve endings

Question 4

M2 location

Answer 4

Heart
SA
AV

Question 5

M3 location

Answer 5

Smooth muscles

Glands

Question 6

Describe the mechanism of far vision

Answer 6

Low Parasymp. tone (M3)
Relaxed ciliary muscles
Flat shape

Question 7

Describe the mechanism of near vision

Answer 7

High Parasymp. tone (M3)
Contracted ciliary muscles
Spherical shape

Question 8

Describe the mechanism of pupillary constriction

What is the name of the muscle?

Answer 8

High Parasymp. tone

Spincter pupillae

Question 9

Describe the mechanism of pupillary dilation

What is the name of the muscle?

Answer 9

High symp. tone

Dilator pupillae

Question 10

Pupillary dilation- which receptor plays a role?

Answer 10

a1

Question 11

High aqueous humor production by what mechanism?

Agonist? Antagonist?

Answer 11

B2 agonists

Question 12

Low aqueous humor production by what mechanism?

Agonist? Antagonist?

Answer 12

a2 agonists

B2 antagonists

Question 13

Direct acting cholinomimetics and which receptors do they activate? (5)

Answer 13

Methacholine- M>N
Bethanechol- M
Pilocarpine- M

Carbachol- M, N

Vareniciline- N

Question 14

I can treat Non obstructive ileus and urinary retention. Whcih drug am I?

Answer 14

Bethanechol

Question 15

Carbachol can treat ____ through which mechanism?

Answer 15

Glaucoma

M-R agonist

Question 16

Pilocarpine can treat

Answer 16

Glaucoma
Xerostomia
(CF sweat test)

Question 17

Which choilnomimetic drug can help with smoking cessation?

Answer 17

Varenciline

Question 18

Indirect acting cholinomimetics 3 groups and drugs of each group

Answer 18

Carbamates- Neostigmine, Pyridostigmine, Physostigmine, Rivastigmine, Galantamine, Donepezil
Organophosphates- Malathion, Parathion, Sarin
Alcohol- Edrophonium

Question 19

Main difference btw. Carbamates and organophosphates?

Answer 19

Carbamates are reversible and organophosphates are irreversible

Question 20

Which Carbamates enter the CNS?

Answer 20

Physostigmine
Rivastigmine
Galatamine
Donepezil

Question 21

Which Indirect acting cholinomimetics can help treat Alzheimer disease?

Answer 21

Rivastigmine
Galantamine
Donepezil

Question 22

Which drug can be used in the DD of Myasthenia Gravis?
What is the test?
What is the other possibility besides MG?

Answer 22

Edrophonium
Tensilon test
Cholinergic crisis (If there is no improved muscle tone)

Question 23

Whcih drug can be given in case of Atropine overdose?

Answer 23

Physostigmine

Question 24

Pyridostigmine main use

Answer 24

Treat MG

Topical in Glaucoma

Question 25

Neostigmine can be used in case of

Answer 25

MG Non obstructive ileus Urinary retention Reversal of NM block

Question 26

AchE Inhibitors poisoning symptoms

Answer 26

``` (DUMBBELS) Diarrhea Urination Miosis Bradycardia Bronchoconstriction Excitation Lacrimation Secretion ```

Question 27

Muscarinic antagonists (12)

Answer 27

``` Atropine Cyclopentolate Scopolamine Butyl-scopolamine Procyclidine Benztropine Trihexyphenidyl Solifenacil Oxybutynin Tolterodine Ipratropium Tiotropium ```

Question 28

Which Muscarinic antagonist have M3 selectivity?

Answer 28

Tiotropium

Question 29

Which Muscarinic antagonist drugs can help treat Parkinson?

Answer 29

Procyclidine Benztropine Trihexyphenidyl

Question 30

Which drug can regenerate cholinesterase?

Answer 30

Pralidoxime

Question 31

Which receptors have pre-synaptic inhibition activity?

Answer 31

a2 | M2

Question 32

Which receptors have pre-synaptic stimulation activity?

Answer 32

M1 B2 AT-1 Prostaglandin

Question 33

Pre-synaptic inhibition drugs (3)

Answer 33

Hemicholinium Vasemicol Botulinium

Question 34

Pre-synaptic stimulation drugs (2)

Answer 34

4- aminopyridine | a- Latrotoxin