Autonomic Pharmacology Flashcards
(36 cards)
Cholinergic receptors
Nicotinic & muscarinic
Adrenergic receptors
alpha & beta
Which receptors does the PSNS use
cholinergic & muscarinic
receptors do the SNS use
adrenergic
What do M1, M3, M5 receptors cause
G protein coupled activators –> cause contraction
What do M2 & M4 receptors cause
inhibitory G protein couple receptors
Cholinergic vs adrenergic in the heart
M2
Adrenergic - increase heart rate
Muscarinic - decrease heart rate
Cholinergic vs adrenergic in the lungs
adrenergic - bronchodilation
cholinergic - bronchoconstriction
Cholinergic vs adrenergic in the sphincters (GI & bladder)
Cholinergic - relaxation
sphincter - opens so you can pee
Cholinergic vs adrenergic in the walls
contraction
Cholinergic vs adrenergic in urination
M3 in bladder - contracts
M3 in sphincter - relaxes
3 types of cholinergic drugs
- Acetylation - rapid recovery, physiological
- Carbamylation - slow recovery, reversible
- phosphorylation - no recovery, ireversible
What drug blocks PSNS responses
parasympatholytics
how do parasympatholytics work
atropine - block the M receptors
what effect (adverse & beneficial) does atropine have
beneficial - clear airways, dilate pupils, counteract poisoning by cholinesterase inhibitors
adverse - dry mouth, tachycardia, constipation, difficulty urinating
what do alpha-1 receptors do
constrict smooth muscles
where are alpha-1 receptors located
sphincters, blood vessels
what do alpha-1 receptors do to blood vessels
vasoconstriction
what do alpha-2 receptros do
inhibit presynaptic norepinephrine release
what do beta-1 receptors do in the heart
stimulate the heart
what do beta-1 receptors do in the kidney
stimulate renin release
what do beta-2 receptors do
relax the smooth muscles
where are beta-2 receptors located
lungs, blood vessels, spinchter
what do beta-2 receptors cause in the lungs
bronchodilation
