Autonomic Receptor Pharmacology

Question 1

Effects of sympathetic stimulation of the eye

Answer 1

A1 - Mydriasis (dilated pupil), B - Increased fluid inflow

Question 2

Effects of sympathetic stimulation of the lung

Answer 2

B2 - Bronchorelaxation (increased airflow)

Question 3

Effects of sympathetic stimulation of the heart

Answer 3

B1 more than B2 - Increased HR (SA node), Increased conduction (AV node), Increased contractility (Ventricle)

Question 4

Effects of sympathetic stimulation of blood vessels

Answer 4

A1 - Constriction (increase BP), B2 - Dilation (skeletal muscle decrease BP)

Question 5

Effects of sympathetic stimulation of stomach

Answer 5

A1,B2 - Decrease in motility, tone and secretion

Question 6

Effects of sympathetic stimulation of intestine

Answer 6

A1,B2 - Decrease in motility and tone (constipation)

Question 7

Effects of sympathetic stimulation of bladder

Answer 7

Relaxation (urinary hesitancy, retention)

Question 8

Effects of sympathetic stimulation of glands

Answer 8

Some secretion

Question 9

Effects of sympathetic stimulation of adrenal medulla

Answer 9

Epi release via nicotinic receptors

Question 10

Effects of sympathetic stimulation of male sex organ

Answer 10

A1 - ejaculation

Question 11

Effects of sympathetic stimulation of pancreas

Answer 11

A2 - Decreased secretion of insulin, B2 - Increased secretion of insulin

Question 12

Effects of sympathetic stimulation of liver

Answer 12

A1, B2 - Gluconeogenesis, glycogenolysis

Question 13

Effects of sympathetic stimulation of uterus (pregnant)

Answer 13

Relaxation

Question 14

Effects of parasympathetic stimulation of eye

Answer 14

Mioisis (constricted pupil), accomodation for near vision, increase in fluid outflow

Question 15

Effects of parasympathetic stimulation of lung

Answer 15

Bronchoconstriction

Question 16

Effects of parasympathetic stimulation of heart

Answer 16

Decrease in HR and contractility

Question 17

Effects of parasympathetic stimulation of blood vessels

Answer 17

Dilation (not significant)

Question 18

Effects of parasympathetic stimulation of stomach

Answer 18

Increase in motility, tone and secretion

Question 19

Effects of parasympathetic stimulation of intestine

Answer 19

Increase in motility and tone (cramps, diarrhea)

Question 20

Effects of parasympathetic stimulation of bladder

Answer 20

Micturation

Question 21

Effects of parasympathetic stimulation of glands

Answer 21

Profuse secretion (sweating, salivation, etc)

Question 22

Effects of parasympathetic stimulation of adrenal medulla

Answer 22

None

Question 23

Effects of parasympathetic stimulation of male sex organ

Answer 23

Erection

Question 24

Effects of parasympathetic stimulation of pancreas

Answer 24

None

Question 25

Effects of parasympathetic stimulation of liver

Answer 25

None

Question 26

Effects of parasympathetic stimulation of uterus (pregnant)

Answer 26

Variable

Question 27

What type of receptor is present at the neuromuscular junction?

Answer 27

Nictotinic (Ach)

Question 28

What is the postganglionic receptor in the parasympathetic system?

Answer 28

Nictotinic (Ach)

Question 29

What is the target organ receptor in the parasympathetic system?

Answer 29

Muscarinic (Ach)

Question 30

What is the postganglionic receptor in the sympathetic nervous system?

Answer 30

Nicotinic (Ach)

Question 31

What is the target organ receptor in the sympathetic nervous system?

Answer 31

Adrenergic (receiving norepinephrine)

Question 32

What sympathetic target receptors are not adrenergic and what are they?

Answer 32

Sweat glands innervated by the sympathetic system use muscarinic receptors

Question 33

How does the muscarinic receptor work?

Answer 33

Stimulation of PLC, increase in IP3 and DAG, then NO-c-GMP (BVs) or decrease c-AMP (heart)

Question 34

What type of receptors are nicotinic receptors?

Answer 34

Ionotropic

Question 35

How do alpha1 receptors work?

Answer 35

Stimulation of phospholipases increase IP3, DAG, and Ca2+

Question 36

How do alpha2 receptors work?

Answer 36

Inhibition of adenylyl cyclase and decrease in c-AMP

Question 37

How do B1 and B2 adrenergic receptors work?

Answer 37

Stimulation of adenylyl cyclase and increase in c-AMP