Autonomics

Question 1

NE synthesis

Answer 1

Tyrosine —[tyrosine hydroxylase]–> DOPA –> dopamine –> NE

Question 2

What transporters are responsible for NE reuptake?

Answer 2

NET (NE transporter) and DAT (DA transporter)

Question 3

if NE is not taken up by NET and DAT, what 2 compounds may metabolize it?

Answer 3

MAO (monoamine oxidase)

COMT

products are then excreted

Question 4

what are the 2 types of cholinergic receptors, and what class of receptor are they

Answer 4

nicotinic
muscarinic

GPCRs

Question 5

which of the following would you give in order to increase HR?

a. beta1 antagonist
b. beta1 agonist
c. beta2 agonist
d. alpha1 antagonist

Answer 5

b. beta1 agonist

Question 6

which receptor does the sympathetic system act on to produce bronchodilation

Answer 6

beta2

Question 7

which receptor does the parasympathetic system act on to cause bronchoconstriction?

Answer 7

M3 receptor

Question 8

sympathetic receptor associated with SA node

Answer 8

acceleration via beta1 (also beta2 but primarily 1)

Question 9

parasympathetic receptor associated with SA node

Answer 9

deceleration via M2

Question 10

skeletal muscle vessels relax in response to sympathetic innervation via ____ receptor

Answer 10

beta2

Question 11

JG apparatus of kidney sympathetic stim causes renin release via ____ receptors

Answer 11

Beta1