Autonomics Pharm Flashcards
(20 cards)
Sweat gland innervation
Sympathetic
ACh - mAChR
Cardiac, smooth muscle, gland cells, nerve terminal parasympathetic innervation
ACh - mAChR
Cardiac and smooth muscle, gland cells, nerve terminals sympathetic
Norepinephrine - alpha and beta receptors
Renal vascular smooth muscle innervation
Sympathetic
Dopamine
Skeletal muscle
Somatic innervation
ACh — nAChR
A1 receptors…
Stimulate contraction of all SM; primary mode of controlling vascular smooth muscle vasoconstriction
B2 receptors..
Relax smooth muscle
Cause vasodilation and are important in lungs, GI, etc
Muscarinic receptors
Contract smooth muscle
M2 receptor
Located in heart, nerves, and SM
GPCR Gi
Inhibits AC, decreases cAMP, and activates K+
M3 receptor
Located in glands, SM, and endothelium
GPCR Gq
Activates PLC, IP3, and DAG cascade
M1
Located in CNS and gangli
GPCR Gq
Activates PLC, IP3, and DAG cascade
M4
Located in CNS
GPCR Gi
Inhibits Ac, decreases cAMP, activates K+
M5
Located in CNS, GPCR Gq, activates PLC, IP3, and DAG cascade
Nm
SKM NMJ
Ligand gated
Na+, K+ depolarize get ion channel
Nn
Post ganglionic cell body, dendrites, CNS
Ligand gated
Na+/K+ depolarizing ion channel
Alpha 1
Gq: increases PLC, IP3, and DAG as well as intracellular Ca2+
Responds to Epi and NE
Causes contraction
Alpha 2
Gi: decreases AC and cAMP
Responds to Epi and NE
Located in pancreatic islets, platelets, nerve terminals, and vascular smooth muscle
Causes decreased insulin secretion
Beta1
Gs
Increases AC, cAMP, L-type Ca2+ channel opening
Responds equally to Epi and NE
Found in heart and juxtaglomerular cells
Increases renin secretion, increases force and rate of contraction via the AV node
Beta2
Gs
Increases AC
Responses more strongly to Epi and NE
Found in SM and SKM
Causes relaxation
Beta3
Gs: increases AC
Responds to NE more than Epi
Found in adipose tissue and will cause lipolysis
