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Host defense > B Cell Immunity > Flashcards

B Cell Immunity Flashcards

(63 cards)

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1
Q

Three kinds of B-cells

A

B1, conventional B2, marginal zone

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2
Q

B cells with hypermutation

A

Conventional B2 (high hypermutation)

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3
Q

B cells that mediate adaptive immunity

A

Conventional B2

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4
Q

Innate-like B cells

A

B1, marginal zone

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5
Q

B cells with memory development

A

Conventional B2

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6
Q

Self-renewing B cells

A

B1

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7
Q

B cells produced before birth

A

B1

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8
Q

B cells produced after birth

A

Conventional B2, marginal zone B cells

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9
Q

B cells that require T cells

A

Conventional B2

sometimes marginal zone B

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10
Q

Produces more IgG than IgM

A

Conventional B2

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11
Q

High immunogenicity of proteins

A

Large size, subcutaneous > intraperitoneal > IV or intragastric, slow release of adjuvants, multiple differences to self protein

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12
Q

High immunogenicity of proteins

A

Large size, subcutaneous > intraperitoneal > IV or intragastric, slow release of adjuvants, multiple differences to self protein

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13
Q

Adjuvant that enhances immune responses

A

Alum (aluminum hydroxide)

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14
Q

T-independent antigens

A

Polysaccharides (no second signal required)

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15
Q

B-cell stimulatory cytokines after activation of Th cells. Proliferation of B-cells

A

IL-4, 5, 6. Also 10

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16
Q

B-cell stimulatory cytokines after activation of Th cells. Proliferation of B-cells

A

IL-4, 5, 6

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17
Q

Do B cells develop in bone marrow in antigen-dependent or -independent manner?

A

Antigen-independent

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18
Q

What enzyme is required for somatic recombination?

A

AID (activation-induced cytidine deaminase)

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19
Q

IL-4 drives which isotype class switch?

A

IgM to IgG1 and IgE

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20
Q

What are switch sites?

A

Sites upstream of regulatory region that help determine isotype switching

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21
Q

Sites of B cell proliferation and differentiation

A

Germinal center

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22
Q

Define somatic hypermutation

A

Changes in variable region to optimize antibody specificity/diversity

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23
Q

Antibodies predominantly observed with antibody-independent T-cells

A

IgM

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24
Q

CD56

A

NKC

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25
CD56
NKC
26
CD34
unique HSC marker
27
CD1A
Expressed by cells committed to T-cell lineage after receiving notch signal from DL4 or 1 begin to rearrange TCRgamma, delta and beta genes. Now in pre-T stage
28
Requirements for rearrangement of TCR genes
RAG1, RAG2, and IL-7
29
Dark zone
Site for somatic hypermutation
30
Light zone
Site for class switch recombination and differentiation
31
Light zone
Site for class switch recombination and differentiation
32
IL13
IgE, Mast cells
33
Hassall’s corpuscles
the site for | generation of regulatory T cells
34
IL-17
Potent recruited of neutrophils
35
IL-17
Potent recruited of neutrophils
36
Humoral immunity
ANTIBODIES
37
Humoral immunity
ANTIBODIES | humoral = fluid
38
Humoral immunity
ANTIBODIES | humoral = fluid
39
TMMI is a host response for ________ pathogens
intracellular
40
TMMI is a host response for ________ pathogens
intracellular
41
Cardinal cytokine in TMMI response
INF-gamma
42
Cardinal cytokine in TMMI response
INF-gamma
43
NK cells are sampling which MHC class proteins?
MHC-I
44
How do NK cells kill?
Direct cytotoxicity, use of FcR that senses that a specific antibody is bound to cell. Punches a hole with perforin, inserts granzymes to kill cell. Fas-FasL cell (apoptosis)
45
Which cells do no present MHC-II
Somatic cells (lungs, gut, etc.)
46
Critical second signal for CD8
IFN-gamma
47
Critical second signal for CD8
IFN-gamma
48
Extracellular infections require what type of response
B cell response (Th2)
49
Extracellular infections require what type of response
B cell response (Th2)
50
Trio of cytokines that activate Th17 immunity
IL-6, IL-23, TGF-B | Ratio of IL-6/TGF-B is crucial
51
Trio of cytokines that activate Th17 immunity
IL-6, IL-23, TGF-B | Ratio of IL-6/TGF-B is crucial
52
CD80, 86 are also known as
B7
53
CD80, 86 are also known as
B7
54
Treg unique TF
CD3, 4, 25+
55
Treg unique TF
CD3, 4, 25+ (along with TFG-beta)
56
Treg unique TF
CD3, 4, 25+ (along with TFG-beta)
57
Control of CTLA-4 expression
FOXP3
58
Control of CTLA-4 expression
FOXP3
59
During ongoing immune rxns, when TGF-beta becomes more dominant thatn IL-6, Th0 cells are converted to ________ at _________ sites
Treg | peripheral (not thymus)
60
During ongoing immune rxns, when TGF-beta becomes more dominant thatn IL-6, Th0 cells are converted to ________ at _________ sites
Treg | peripheral (not thymus)
61
Memory CD8 T cells are extremely sensitive to this interleukin
IL-21
62
Memory CD8 T cells are extremely sensitive to this interleukin
IL-21
63
CD-4 RM
rely on antigen presence

Host defense (9 decks)

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