B Cell Immunity Flashcards
(24 cards)
What are the Co-BCR receptors?
CD19, CD81 and CR2/CD21
Naive B cells entering lymph nodes express
L selectin, CXCR5 and LFA-1
What is the B cell adaptor protein?
Syk-B
TfH secrete what cytokine for B cell survival
IL-21
IL-4 primary isotype switch
IgG1 and IgE
Il-5 primary isotype switch
IgA
IFN-Y primary isotype switch
IgG2a and IgG3
TGF-B primary isotype switch
IgG2b and IgA
AID function
Involved in somatic hypermutation that converts Cs to Us
CD27
B plasma cell marker
Memory B cell markers
Cd27 and CD45
Memory B cell anti-apoptotic protein
Bcl-2
What is unique about t independent b cell act?
No class switching, no affinity matu and little to no memory. IgM uses for short term antibody protection.
B cell inhibitory receptor
FcyRIIB
FcYRI also known as
CD64
FcYRI
(CD64) involved in phagocytosis and act. of phagocytes like macro, neutro and eosinoph.
FcYRIIA and FcYRIIB also known as
CD32
FcYRIIA
Less inefficient cell activation and phagocytosis. Act. macro, neuto, eosinop. and platelets.
FcYRIIB
Involved in feedback inhibition of B cells and attentuation of inflamm. Act. B lymph, DCs, mast cells, neut. and macro.
FcYRIIIA also known as
CD16
FcYRIIIA
Involved in antibody dependent cellular cytoxicity(ADCC). Involves NK cells.
FceRI
Activation or degranulation of mast and basophils. Involves mast, baso and eosin.
FcRn
Neonatal, IgG specific. Maintain IgG levels and increases Half life of it too.
FcRn on
APCS Neut Vascular endothelium Mucosal epithelial cells Podocytes
