b-cell maturation Flashcards
1
Q
where does b-cell maturation occur
A
in bone marrow or lymph node
2
Q
what is b-cell maturation
A
stem cells mature and produces BCRs (b-cell receptors)
3
Q
what does b-cell maturation develop
A
surface markers to take care of antigen
(express antigen specific antibodies)
4
Q
what are the surface markers that b-cells develop
A
cd45r and IL-7 receptor
5
Q
what is IL-7 receptor produced by
A
stromal cells
6
Q
what does the IL-7 receptor do
A
critical in driving further differentiation and proliferation of the B cell
7
Q
what is BCR
A
significant sensor for an antigen that is required for B-cell activation, survival, and development
8
Q
describe BCRs
A
heavy and light chains
V,D, AND J genes
