B. Immune Suppression Flashcards
Starting from Immune supression to Manifestation of E. Histolytica (41 cards)
Example of immune suppression in which there is polyclonal hypergammaglobulinemia where antibodies lack specificity against these parasites.
Filarial infections with Wuchereria bancrofti and Brugia malayi
Example of immune suppression in which the immune response is directed against the deeper layer of its cuticle but the immune response is diverted to the rapidly changing surface of its integument
Necator americanus infection
Example of immune suppression in which the immune complexes are produced which suppress inflammatory response through inhibition of complement activity
Cysticercus cellulosae infection
Example of immune suppression in which the compliment cannot participate in the destruction of the parasite since the complement is consumed by the soluble antigens of Schistosoma spp.
Schistosoma spp. infection
It is a parasite evasion mechanism in which the major mechanism of possibly evading the host immune surveillance is by altering its surface proteins to avoid identification
Antigenic variation
Example of antigenic variation in which the parasites change the antigenic profile of their surface coat through variant surface glycoproteins
Tripanosoma brucei infection
A parasite in which provide an example of antigenic variation in which the surface protein variation has also been observed
Giardia lamblia
A parasite in which provide an example of antigenic variation in which the surface protein variation has also been observed
Giardia lamblia
This malarial parasites exhibit antigenic diversity through repeat variation of the encoded polypeptides which contain tandem sequences of amino acids as observed in merozoite surface antigen and ring erythrocyte surface antigen
Plasmodium falciparum
This malarial parasites exhibit antigenic diversity through repeat variation of the encoded polypeptides which contain tandem sequences of amino acids as observed in merozoite surface antigen and ring erythrocyte surface antigen
Plasmodium falciparum
A parasite evasion mechanism in which similarities of the parasite and the host enables the parasite to avoid the host immune response. Antibodies produced against the parasite then fail to recognize non-self from self antigens.
Host mimicry
Example of host mimicry in which the hydatid cyst has been found to carry p blood group antigen
Larval stage of echinococcus granulosus
Example of host mimicry in which the hydatid cyst has been found to carry p blood group antigen
Larval stage of echinococcus granulosus
Example of host mimicry in which the tegument of this parasite can acquire antigenic molecules from the host
Schistosoma spp.
An example of parasite evasion mechanism in which ones the intracellular parasite escape immune response
Intracellular sequestration
This parasites proliferate in macrophages of various organs
Amastigotes of Trypanosoma cruzi and Leishmania spp.
Example of parasite under intracellular sequestration in which can multiply in macrophages and other nucleated cells
Toxoplasma gondii
The adverse effect of immune response in host can cause by hyperactivity or hypoactivity
Hyperactivity
Acute infection of this parasite can lead to heart failure and meningoencephalitis it is believed to cause by intense immune response damaging the surrounding nerve cells and myocytes
Trypanosoma cruzi
This parasite can cause overproduction of Igm or polyclonal hypergammaglubolenemia due to T-surpressor cell defect, it can also cause large number of immune complexes in tropical pulmonary eosinophilia
Wuchereria bancrofti
During recurrent infections of this parasite, immune complexes are associated with hyperactive malarious splenomegaly
Plasmodium spp.
This parasite can cause immune complexes to be deposited in the basement membrane of glomeruli leading to kidney failure and nephrotic syndrome it can also occur in Schistosomiasis
Plasmodium malariae
Late intraerytrocytic sequestration of this parasite and their attachment to endothelial cells is protective to the parasite but believed to be the cause of cerebral malaria
Plasmodium falciparum
In many clinical manifestation this parasites are related to the immune response to the eggs trap in the organ of the host, it can results in hepatosplenomegaly, fibrosis, increase portal hypertension and esophageal varices, can also increase the levels of its antigen in immune complexes can produce a condition like serum sickness
Schistosoma spp.
