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IBI Test 3 > B3-073 CBCL Lymphoma > Flashcards

B3-073 CBCL Lymphoma Flashcards

(68 cards)

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1
Q

disease limited to 1 anatomic region or 2 contiguous regions on the same side of diapragm

A

stage 1

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2
Q

disease in more than two anatomic regions or in the noncontigous regions on the same side of the diaphragm

A

stage 2

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3
Q

disease on both sides of diapragm but limited involvement of lymph nodes and spleen

A

stage 3

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4
Q

disease of any lymph node with involvement of the liver, lung, and bone marrow

A

stage 4

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5
Q

waldenstrom macroglobinunemia

A

LPL

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6
Q

MYD88 L265P mutation

A

LPL

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7
Q

sIg +
CD5+
CD20+
CD23+

A

CLL/SLL

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8
Q

sIg+
CD20+
FMC7 +

A

Marginal zone

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9
Q

sIg+
CD10+
CD20+
FMC7+

A

follicular lymphoma

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10
Q

sIg+
CD5+
CD20+
FMC7+
cyclin D1+

A

mantle cell

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11
Q

sIg+
CD20+
FMC7+

A

LPL

lymphoplasmacytic lymphoma

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12
Q

t(14;18)

A

follicular lymphoma

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13
Q

t(11;18)

A

marginal zone lymphoma

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14
Q

t(11;14)

A

mantle cell lymphoma

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15
Q

positive SOX11 stain

A

mantle cell lymphoma

marker for cyclin D1 negative MCL

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16
Q

nucleus size more than twice of nomal lymphocyte

A

diffuse large b cell

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17
Q

occur in equatorial Africa

A

endemic Burkitt

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18
Q

t(8;14)

A

Burkitt lymphoma

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19
Q

which leukemia/lymphoma is most common in children

A

ALL

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20
Q

spreads in an orderly fashion to contiguous lymph node groups

A

Hodgkin

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21
Q

most common cell of origin for non-hodgkin lymphomas?

A

B cell

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22
Q

most common leukemia in US

A

CLL

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23
Q

lymphocytosis
smudge cells

A

CLL

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24
Q

blasts are associated with

A

AML or ALL

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25
granulocytic leukocytosis is associated with
CML
26
circulating plasma cells characterizes
plasma cell leukemia | rare complication of plasma cell myeloma
27
presence of ....... is favorable for CLL
somatic hypermutation
28
t(14, 18)
follicular lymphoma
29
t(14;18) causes overexpression of
Bcl-2 | follicular lymphoma
30
t(8;14)
Burkitt
31
t(8;14) causes overexpression of
MYC | Burkitt
32
t(11;14)
mantle cell
33
t(11; 14) causes over expression of
cyclin D1 | mantle cell lymphoma
34
t(15;17)
APL
35
trisomy 12
CLL
36
t(11;18)
marginal zone lymphoma
37
c-MYC is located on chromosome
8
38
most common type of non hodgkin lymphoma
diffuse large B cell | follicular lymphoma is second most common
39
second most common type of non-hodgkin lymphoma
follicular
40
Burkitt | starry sky
41
Burkitt lymphoma has a high association with what virus
EBV
42
CD20+ CD10+ TdT-
Burkitt
43
waldenstrom macroglobulinemia is associated with
Lymphoplastic lymphoma (LPL)
44
monoclonal gammopathy of undetermined significance with an IgG or IgA paraprotein is most likely to transform into
plasma cell myeloma
45
rouleux is associated with
plasma cell myeloma
46
rouleux is caused by
large amount of paraprotein
47
waldenstrom macroglobulinemia is associated with what paraprotein?
IgM
48
BRAF mutation is associated with
hairy cell leukemia
49
reed sternburg cells are diagnostic for
hodgkin
50
CD15+ CD30+
hodgkin
51
what immunophenotype do Hodgkins cells express?
CD15 CD30
52
commonly occurs in young adults and adolescents
Hodgkin
53
associated with HTLV-1 infection
adult t cell leukemia
54
what 2 lymphomas are associated with CD5+?
mantle cell SLL
55
how to distinguish mantle cell from SLL?
mantle cell is CD23- Cyclin D1+ and t(11;14)
56
CD20+ CD5+ CD23-
mantle cell lymphoma
57
what CDs characterize mantle cell lymphoma?
CD20+ CD5+ CD23- CyclinD1 +
58
[T/F] Hodgkin lymphoma has TCR rearrangement
false
59
[T/F] T cell lymphomas are the most common non-Hodgkin lymphomas
false | B cell
60
[T/F] CLL/SLL without transformation is considered aggressive
false | indolent
61
[T/F] richters transformation is a rare complication of diffuse B cell lymphoma
false | CLL/SLL
62
[T/F] low grade follicular lymphoma can transform to more aggressive double or triple hits lymphoma
true
63
[T/F] mantle cell lymphoma is characterized by monoclonal B cells that are CD5 and cyclin D1 positive
True
64
[T/F] richters transformation of CLL/SLL can be diffuse large B cell lymphoma of Hodgkin lymphoma
true
65
[T/F] IgH gene rearrangement is present in mantle cell lymphoma
true
66
[T/F] hodgkin lymphoma includes classical and nodular lymphocyte dedominant subtypes
true
67
[T/F] NK cell lymphoma has both TCR and IgH rearrangement
false
68
t(11;18)
marginal zone lymphoma

IBI Test 3 (20 decks)

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