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Flashcards in Bacillus Deck (13):
1

All bacillus species are motile via flagella, except what?

Bacillus anthracis

2

The growth of Bacillus anthracis is inhibited by ____, such as is found in dead carcasses.

CO2

3

  1. What is Bacillus anthracis resistant to?
  2. What can kill Bacillus anthracis?

  1. Resistant to:
    • Phenol disinfectants
    • Boiling for 20 minutes
  2. Killed by:
    • Formalin
    • Autoclaving

    ***THE VEGETATIVE FORM IS READILY KILLED***

4

Bacillus anthracis produces a three-part toxin.  What are the 3 parts of that toxin?

Lethal factor

Edema factor

Protective antigen

5

Toxin production is dependent upon the presence of a large plasmid which can be eliminated by passage at _____ or exposure of culture to _____.

Toxin production is dependent upon the presence of a large plasmid which can be eliminated by passage at 42.5 degrees C or exposure of culture to antibiotic novobiocin.

6

  1. Which part(s) of the 3 part toxin act a B (binding) unit?
  2. Which part(s) of the 3 part toxin act as an A-subunit?

  1. Protective antigen
  2. Edema factor & lethal factor

7

Which toxin has the following action:

Attaches to the cell receptor and undergoes proteolytic cleavage.  By remaining bound to the cell, this toxin serves as a docking station for binding of other toxin parts.

Protective antigen

8

What does edema factor activate?

Adenylate cyclase

9

What does lethal factor cleave?

Kinase involved in signal transduction in CD4+ T-lymphocytes and fibroblasts

10

Which toxin inhibts IL-2 production and proliferative responses in the CD4+ T cells, thereby blocking fuctions that are pivotal in the regulation of the immune response?

Lethal factor

11

What is the Bacillus anthracis capsule composed of?

Poly-D glutamic acid

12

Which organism is distributed worldwide, especially in alkaline soils with high N content with alternating flooding and drying periods?

Bacillus anthracis

13