Bact PNA (lec 12) Flashcards by Wendy Pitts

Cause of PNA: Φ predisposing factors?

pneumoniae:
Mycoplasma (no wall)
Strep (+)
Chlamy (-)

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Cause of PNA: alcoholics/homeless/DM?

pneumoniae:
Strep (+)
Kleb (-)

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Cause of PNA: underlying dz?

Strep pneumo (+)
H. flu (-)
P. aerug (-)
Staph aureus (+)

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Cause of PNA: vent pts?

K. pneumo (-)

P. aerug (-)

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Cause of PNA: travel/occupational?

Legion pneumo (-)

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Cause of PNA: Community Acquired?

S. pneumo (+)
K. pneumo (-)
H. flu (-)
S. aureus (+)

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Atypical PNA: zoonotic pathogens?

Chlam psittaci
Fran tularensis (-)
Cox burnetii (-)

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Atypical PNA: non-zoo pathogens?

Chlam pneumo (-)
M. pneumo (no wall)
Leg. pneumo (-)

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Atypical PNA presentation:

Onset/Appearance?

Temp?

Chills/Shakes?

Cough?

Pleurisy?

CXR?

Other sxs?

Onset: gradual, Appearance: well

Temp: < 103

Chills/Shakes: rare

Cough: dry

Pleurisy: rare

CXR: patchy, undefined infiltrate

Other sxs: GI, aches

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Atypical PNA resistant to what drugs?

β-lactams

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Typical PNA presentation:

Onset/Appearance?

Temp?

Chills/Shakes?

Cough?

Pleurisy?

CXR?

Other sxs?

Onset: sudden, Appearance: sick

Temp: >103

Chills/Shakes: common

Cough: productive

Pleurisy: frequent

CXR: consolidation

Other sxs: chest pain, SOB

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Strep pneumo microbe characteristics?

G+ diplococcus lances
⍺-hemolytic (green colonies)
Optochin sensitive (clearance around op disk)
Bile will lyse

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Strep pneumo epidemiology?

young/old
cold/wet months
reservoir: asympt carriers

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Strep pneumo Virulence Factor result of?

CAPSULE:
Φ phagocytosis
Φ complement
Φ opsonization by C3b

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S. pneumo protection factors?

IgA protease: Φ host IgA

H2O2 prodxn: lyse host, kill competition

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S. pneumo binding factors?

Pili: activate TNF

Surface proteins: bind choline on epi cells

S. pneumo Pneumolysin is?

cytotoxin that forms pores in host membrane ->
lyse host,
activate complement

S. pneumo Autolysin is?

enzyme produced in response to abx:
lyses host and pneumococcus ->
release pneumolysin,
↓ host immune response

S. pneumo action?

causes immune response, allows replication of micorbe

fluid fills alveoli -> RBC/WBC -> consolidation

S. pneumo resolution?

fluid reab and phago of bacteria

S. pneumo diagnostic tests?

Aggultination = capsular polysacc

Genetic Probe = s. pneumo rRNA

S. pneumo tx?

PCN G

Klebsiella pneumoniae microbe characteristics?

G- bacillus

Slime capsule

K. pneumo epidemiology?

Normal intest flora, aspirated

Nosocomal

K. pneumo Virulence Factors?

POLYSACC CAPSULE: Φ phagocytosis Φ MAC lysis Adhesion

K. pneumo action?

Causes typical CAP/Nosocom: necrosis of alv spaces, up lobes -> inflamm and hemorr (C) fatal

K. pneumo presentation?

acute onset high fever hemoptysis (currant jelly sputum) abscess, cavitation

K. pneumo diagnostic tests?

``` Cx = mucoid capsule CXR = cavitation ```

K. pneumo tx?

aminoglyco + 3rd gen cephalo + fluoro

Mycoplasma pneumo microbe characteristics?

Φ cell wall "Fried egg" in culture Sterols in plasma memb

M. pneumo action?

Adhesion to epith -> release H2O2, Φ airway clearance, hides w/i host memb

M. pneumo causes what infections?

Atyp PNA otitis rhinitis pharyngitis tracheobronch

M. pneumo epidemiology?

(U) 5-20yo | Reservoir: p-to-p resp droplets

M. pneumo diagnostic tests?

CXR = patchy infilt Cx = mulberry colonies Cold Agg = IgM's bind I antigen of RBC

M. pneumo DOC?

Azith/TCN

Chlamydophila pneumo microbe characteristics?

G- cocci Obligate INTRACELLULAR parasite ``` 2 Forms: Elementary Bodies (infectious) Retic Bodies (intracellular) ```

C. pneumo action?

Inflamm response, | Tissue destruction by bact replication

C. pneumo epidemiology?

>60yo | Reservoir: p-to-p resp droplets

C. pneumo DOC?

TCN/Erythro