Bacterial Pathogenesis Flashcards Preview

Microbiology and Immunology > Bacterial Pathogenesis > Flashcards

Flashcards in Bacterial Pathogenesis Deck (2):
1

Superantigens

Toxins produced by (particularly G+) bacteria

e.g. TSS caused by S. aureus (related to menstruation) but also sometimes by S. pyrogenes (rash, fever, hypotension and death in children)

2

What is the mechanism of superantigen presentation?

  • binds directly to MHC II
  • does not get processed in the APC
  • defining characteristic of superantigens is beta-chain specificity
    • binds to specific beta-chain T-cell receptors
    • ~20% of T-cells tf causes massive inflammatory response --> shock