Bacterial Pathogenesis Flashcards
(17 cards)
Adherence factor that causes adherence to erythrocytes
Filamentous hemagglutinin
Adherence factor that help attach solid bacteria to solid surfaces
Fimbriae
Adherence factor that inhibits phagocytosis and aids in adherence
Glycocalyx or capsule
Adherence factor that bind bacteria together for transfer of genetic material
Pili
Adherence factor that is a tenacious bacterial film that is less compact than capsule
Slime
Adherence factors that are cell wall components in gram-positive bacteria that aid in adhesion
Teichoic and lipoteichoic acid
Bacterial extracellular substances that act against the host by breaking down 1’ or 2’ defenses of the body aiding the pathogen in invading a host
Invasins
Most invasins are proteins (enzymes) that act to damage host cells and/or have effect of facilitating the growth and spread of the pathogen.
Most invasins are proteins (enzymes) that act LOCALLY to damage host cells and/or have IMMEDIATE effect of facilitating the growth and spread of the pathogen.
Invasive factor that degrades hyaluronic acid between cells
Hyaluronidase
Invasive factor that splits collagen protein
Collagenase
Invasive factor that splits lecithin of membrane
Lecithinase
Invasive factor that clots fibrin
Coagulase
Invasive factor that lyses fibrin clots
Fibrinolysin
Invasive factor that degrades proteins, NAs, and fats
Protease, nuclease, lipase
Invasive factor that lyses RBCs
hemolysin
Invasive factor that lyses leukocytes
Leukocidin
Endotoxin or exotoxin?
1.
a. Mostly from gram-positive
b. Mostly from gram-negative
2.
a. Metabolic product of a growing cell
b. Present in LPS of outer membrane of cell wall and released with destruction of cell or during cell division
3.
a. Lipid portion of LPS of outer membrane
b. Proteins, usually with 2 parts
4.
a. Specific for a particular cell structure or function in the host
b. General, such as fever, weaknesses, aches, and shock; all produce the same effects
5.
a. Heat stable, can withstand autoclaving
b. Heat unstable
6.
a. Low toxicity
b. High toxicity
7.
a. Fever-producing
b. Not fever-producing
8.
a. Not easily neutralized by antitoxin thus, effective toxoids cannot be made to immunize against toxin
b. Can be converted to toxoids to immunize against toxin, neutralized by antitoxin
9.
a. Lethal dose is small
b. Lethal dose is considerably larger
10.
a. Representative diseases: Gas gangrene, tetanus, botulism, diphtheria, scarlet fever
b. Representative diseases: Typhoid fever, UTIs, meningococcal meningitis
1.
a. Exotoxin
b. Endotoxin
2.
a. Exotoxin
b. Endotoxin
3.
a. Endotoxin
b. Exotoxin
4
a. Exotoxin
b. Endotoxin
5.
a. Endotoxin
b. Exotoxin
6.
a. Endotoxin
b. Exotoxin
7.
a. Endotoxin
b. Exotoxin
8.
a. Endotoxin
b. Exotoxin
9.
a. Exotoxin
b. Endotoxin
10.
a. Exotoxin
b. Endotoxin
