Bacterial virulence Flashcards
1
Q
What is virulence?
A
The capacity of organism to cause damage to it’s host
2
Q
Name three of S. aureus’ virulence factors and it’s role.
A
Fibrinogen-binding protein (adhesion)
Leukocidin (kills leukocytes)
TSST-1- toxin- causes shock, rash, desquamation
3
Q
Why does virulence within a species of bacteria vary?
A
Varying possession/expression of genes encoding virulence factors
4
Q
What do superantigens do?
A
Cause non-specific activation of T-cells and massive cytokine release, leading to an inappropriately severe immune response
5
Q
What skin infections is Strep pyogenes often responsible for?
A
Impetigo
Cellulitis
Necrotising fasciitis
