Basic bone biology

Question 1

What is the role of osteoblasts?

Answer 1

Bone formation

Question 2

How are osteoblasts produced?

Answer 2

1) Mesenchymal progenitor cells —>
2) –> Pre-osteoblast –>
3) –> Osteoblast

Question 3

How are osteoclasts produced?

Answer 3

1) Myeloid progenitor cell –>
2) –> Pre-osteoclast –>
3) –> Osteoclast

Question 4

What is the role of osteoclasts?

Answer 4

Bone resorption

Question 5

How is Vitamin D produced by the sun?

Answer 5

1) Skin = 7DHC
2) Liver = 25 (OH) Vit D
3) Kidney = 1,25 (OH)2 Vit D