Basic Immunity

Question 1

TCR

Answer 1

T-cell Receptor

Antigen receptor (surface receptor that recognizes antigens) on T-cells

Question 2

TRUE/FALSE

CD4/CD8 markers are found on T- and B- cells

Answer 2

False

Only T-cells, not B-cells

CD: Cluster of differentiation

Question 3

What is the method of counting or visualization of T-cells?

Answer 3

Rosette Formation with sheep RBC

Question 4

What is the method of counting or visualization of B-cells?

Answer 4

Immunoflorescence with antiglobulin

Question 5

What are the primary lymphoid organs

Answer 5

1. Bone marrow
2. Thymus

Question 6

TRUE/FALSE

B-cells are found at the nodules in the Thymus while the T-cells are found between the nodules at the paracortex area

Answer 6

False

B-cell are absent in the Thymus - only T-cells

The arrangement describe is that of a lymph node

Question 7

What are the Surface receptors on the NK cells

Answer 7

• Lectin-like NK cell receptor (for proteins)
• Killer Ig-like receptor (for MHC class I)

Question 8

What are the types of Dendritic cells

Answer 8

• cDC - classical dendritic cells
• pDC - plasmacytoid dendritic cells
• moDC - monocyte derived dendritic cells

Question 9

ADCC

Answer 9

Antibody-dependent cellular cytotoxicity

Question 10

TSLP

Answer 10

Thymic Stromal Lymphopoietin

Secreted during: Tissue damage, allergens, & parasitic infections
Received by: Innate lymphoid cells Type 2

Response: (IL-4. -5. -13. Areg) for mucus production, vasodilation, thermoregulation, tissue repair, alternative macrophage activation

Question 11

HLA

Answer 11

Human Leukocyte Antigen (System)

Question 11

What activates the Innate lymphoid cells (ILC) type 3

What does it secrete in response

Answer 11

(1) IL-23, IL-1B

(2) IL-17, IL-22, LT-a1b2, GM-CSF

Question 12

3 Groups of Genes in HLA

Answer 12

• class I - transplantation antigen
• class II - cell membrane antigen
• class III - complement proteins and cytokines

Question 13

What is the position of your HLA gene?

Answer 13

Chromosome 6 short arm

Question 14

CD(4 or 8)+ and MHC on Tcell matching

Answer 14

• CD4+ for MHC class 2
• CD8+ for MHC class 1

Question 15

Lysozyme MOA

Answer 15

destroys bacterial cell walls

Question 16

CXCR

Answer 16

Chemokine Receptor

Question 17

Mucus is composed of

Answer 17

mucin, proteins, proteases, protease inhibitors

Question 18

PAMPS + PRR

Answer 18

• pathogen associated molecular patterns (on pathogens)
• pattern recognition receptor (on host defense cells)

Question 19

TLR 2

Answer 19

Ligands from gram positive bacteria

Question 20

TLR 3

Answer 20

dsRNA virus

Question 21

TLR 4

Answer 21

LPS from gram negative bacteria

Question 22

TLR 5

Answer 22

Pilin and Flagellin

Question 23

TLR 7 and TLR 8

Answer 23

ssRNA

Question 24

PRRs that are a family of membrane bound receptors

Answer 24

Toll-like Receptors

Question 26

PRRs that serve as intracellular sensors for microbial products located in the cytoplasm

Answer 26

NOD-like receptors (NLR)

NOD: Nucleotide oligomerization domain

Question 27

PRRs that are a specified intracellular receptor for ssRNA

Answer 27

RIG-like Receptors

RIG: Retinoid Inducible Gene

Question 28

DAMPS

Answer 28

Damage-Associated Molecular Patterns

Products released by injured cells

Question 29

What are the chemoattractants/ cytokines (CXC) of phagocytosis

Answer 29

• IL-8
• C5a
• Opsonin: IgG and C3b

Question 30

IL-8

Answer 30

Attracts neutrophils

Question 31

IL-12

Answer 31

attracts Nk cells

Question 31

IL-17

Answer 31

During allergy