Basic Pharm Principles Flashcards
(59 cards)
pharmacotherapeutics
use of drug to prevent, treat, or diagnose a disease
pharmacodynamics
what drug does to body
pharmacogenetics
genetic basis for drug responses (person to person variation)
pharmacokinetics
what body does to drug (metabolism)
toxicology
study of harmful effects of chemicals
pharmacy
prep and dispensing of medications
relevance of pharm in PT
- most pts will be on medication
- PT can alter rxn to drugs and be altered by drugs
chemical name
compound structure
generic name
often derived from chemical name
trade name
via individual manufacturer
what ensures generic and brand-name drugs are equally safe and effective
same type and amount of active ingredients, same admin route, same pharmacokinetics, same therpeutic effects
phases of drug development and approval
in vitro, animal testing, clinical testing, new drug application, marketing to general public
in vitro studies time
0-2 years
in vitro studies function
lead compound = biologic products + chemical synthesis
animal testing time
years 2-4
animal testing function
efficacy selectivity mechanism
clinical testing time
years 4-8
amount of subjects in phase 1 of clinical testing?
20-100 subjects
phase 1 of clinical testing function
test out basic pharmacology (is it safe)
amount of subjects in phase 2 of clinical testing?
100-200
phase 2 clinical testing function
does it work in patients?
amount of subjects in phase 3 of clinical testing?
1000-6000
phase 3 of clinical testing function
does it work? double blind?
when does the new drug application occur
years 8-9
