Basic Studies

Question 1

% of high grade serous ovarian cancers having deficiency in homologous recombination repair HRR?

Answer 1

Thought to be 50%

Question 2

% of HRm including BRCA1&2 (50&25%) in GOG 218 population (CP+/-Bev) ~ cancer histology subtype?

Answer 2

HGSc, unspecified, endometrioid and clear cell: 21-27%

LGSC- 11%, p=0.02

Question 3

Type of HRm in GOG 218 population (CP+/-Bev): effect on PFS and OS?

Answer 3

/\ HRm associated with /PFS and /OS

most pronounced effect for BRCA-2
BRCA-1 = other HRm