BAsics Flashcards

1
Q

An intricate network of microfilaments that extend throughout the cytoplasm

A

Cytoskeleton

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2
Q

Is cytoskeleton dynamic?

A

yes

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3
Q

Is cytosketon only bone?

A

No, it is also muscle

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4
Q

3 Imp. role of cytoskeleton

A
  1. Cell shape 2. Cells to organoze its internal compartments 3. cells to move
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5
Q

IF protein

A

Fibrous

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6
Q

MT

A

globular tibulin subunit

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7
Q

AF

A

Globular sctin

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8
Q

IF diameter

A

10nm

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9
Q

IF found?

A

Nuclear Lamina

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10
Q

I

IF basic str.

A

Rope like fiber

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11
Q

MT basic str

A

Hollow cylinder

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12
Q

MT diameter

A

25 nm

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13
Q

AF or microF diameter

A

7nm

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14
Q

AF basic str.

A

HELICAL POLYMER OF ACTIN

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15
Q

AF 4 LOCATIONS

A

MIcrovilli
contractile bundles in cytoplasm
filopodia
contractile ring

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16
Q

Cytoskeleton with polarity

A

MT
ACTIN FILAMENT

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17
Q

Actin monomers carry ATP Or GTP

A

ATP

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18
Q

MT carry ATP Or GTP

A

GTP

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19
Q

Treadmilling of Actin filament or MT?

A

ACTIN F.

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20
Q

of Actin filament or MT?
Dynamic instability

A

MT

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21
Q

Simultaneous gain of monomers at the plus end and loss at minus end

A

Treadmilling

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22
Q

Rapid switch from growth to shrinkage at the +end

A

Dynamic instability

23
Q

drug that prevent actin polymerization

A

Cytochalasin
Latrunculin

24
Q

drug that stabilize actin filament from depolarization

A

Phalloidin

25
Proteins that keep actin monomers from polymerizing
Thymosin Profilin
26
# A Actin binding proteins that promote actin polymeerization
Formins Actin Related Proteins ARPs
27
Monomeric GTPase family that regulate actin cytoskeleton
Rho protein
28
Toughest and most durable cytoskeletal filament
IF
29
CK that forms Nuclear Lamina
IF
30
CK that forms Desmosomes
IF
31
Covalent or non covalent int. btw IF
NON COVA
32
Terminal domains of IF same or diferent in different type of IF
Differeent in size and amino acid sequence
33
Class 1 and 2 IF
Acdic keratin BAsic K.
34
Class 3 IF
DEsmin, GFAP,Vimentin
35
Class 4 IF
Neurofilaments
36
Class 5 IF
LAMINS
37
LAmins are Phosphorylated by which kinase
CDK
38
MT Subunits
alpha and beta
39
MT FUNCTION
1. Transporting, positioning memb-bound organelles, within cell 2. Guiding intracellulartransport of cytosolicmacromolecules
40
Disorder when nuclear lamin defect
Progeria | Rare class of premature aging ## Footnote Paa movie
41
The tubulin dimer stack by what kind of interaction
Noncoavalent
42
MT has how many parallel protofilaments
13
43
Tubulin in = and - end of MT
PLUS BETA TUBULIN MINUS ALPHA
44
MT grows at which end
+
45
MTOC in animal cell
Centrosome
46
Centrosome made of what kind of tubulin
GAmma
47
Starting point or nucleating dite for groth of one MT
Each gamma tubulin ring complex
48
Which end of MT is embedded in centrosome
-
49
When does centriole has a role as organising center for MT
cILIA ND fLAGELLA BAsaal bodies
50
Beating of cilia is regulated by
Nexin | MT
51
Ck that position organelles in position
MT
52
Imp. Actin binding protein that promote actin polymerization
Formin
53