Basics

Question 1

Genetic Basis of Acquiring Drug Resistance

Answer 1

1. Transformation
2. Transduction
3. Conjugation
4. Transposition

Question 2

Biochemical Methods of Resistance

Answer 2

1. Decreased intracellular drug level by decreasing drug entry or increasing drug efflux
2. Increase drug inactivation-bacteria produce enzymes that make antibiotics inert
3. Decreased conversion of a drug to a more active compound
4. Increased concentration of a metabolite that antagonizes drug action
5. Change in amount of target enzyme or receptor
6. Decreased affinity of receptor for drug
7. Decreased Activity of an Enzyme Required for the drug to work