bbh203 Flashcards
(58 cards)
What are postsynaptic potentials (PSPs)?
Types of PSPs include:
* Excitatory postsynaptic potentials (EPSPs)
* Inhibitory postsynaptic potentials (IPSPs)
PSPs are changes in the membrane potential of a postsynaptic neuron due to neurotransmitter binding.
What is spatial summation?
Spatial summation involves several presynaptic sources contributing to the postsynaptic potential
It integrates multiple signals from different neurons.
What is temporal summation?
Temporal summation involves the only presynaptic source contributing to the postsynaptic potential
It integrates signals over time from a single neuron.
What are ionotropic receptors?
Ionotropic receptors mediate an instant (or very fast) response
They directly control the flow of ions across the membrane.
What are metabotropic receptors?
Metabotropic receptors mediate a measured (slower) response
They often activate second messenger systems.
What are the three mechanisms for terminating neurotransmission?
The three mechanisms are:
* Diffusion
* Reuptake
* Enzymatic degradation
These mechanisms prevent disorders that could arise if neurotransmission were unregulated.
Define pharmacology.
Pharmacology is the study of drugs and their effects on the body
It encompasses various branches including neuropharmacology and psychopharmacology.
What is a psychoactive drug?
A psychoactive drug is a substance that affects mood, perception, or consciousness
These drugs can alter brain function and behavior.
What is an agonist?
An agonist is a ligand that mimics neurotransmitters at their receptors
It activates the receptor to produce a biological response.
What is an antagonist?
An antagonist is a ligand that blocks neurotransmitters from binding to their receptors
It inhibits the receptor’s biological response.
What is an allosteric modulator?
An allosteric modulator binds to an alternate receptor site to manipulate receptor function
It can enhance or inhibit the receptor’s response to the primary ligand.
What is pharmacodynamics?
Pharmacodynamics refers to the effects of a drug on the body, including:
* Efficacy
* Binding affinity
It examines how drugs interact with their targets.
What is pharmacokinetics?
Pharmacokinetics is the study of how the body absorbs, distributes, metabolizes, and excretes drugs
It focuses on the time course of drug action.
What is metabolic tolerance?
Metabolic tolerance affects how well drugs move through your body
It can alter the metabolism of drugs, affecting their efficacy.
What is functional tolerance?
Functional tolerance affects the frequency of postsynaptic receptor expression
It may result from prolonged drug use leading to receptor adjustments.
What is cross-tolerance?
Cross-tolerance occurs when tolerance to one drug results in tolerance to another drug
This often happens with drugs that act on the same receptor system.
What is the ectoderm?
The ectoderm is the outermost layer of the gastrula from which the nervous system develops
It gives rise to the brain and spinal cord.
What does the notochord do?
The notochord induces the formation of the neural plate
It is essential for the development of the nervous system.
What are the primary vesicles of the neural tube?
The primary vesicles are:
* Prosencephalon
* Mesencephalon
* Rhombencephalon
These vesicles further develop into brain structures.
What are the secondary vesicles of the neural tube?
The secondary vesicles are:
* Telencephalon
* Diencephalon
* Mesencephalon
* Metencephalon
* Myelencephalon
Each corresponds to specific brain regions.
What is anencephaly?
Anencephaly is a condition characterized by the absence of a major portion of the brain
It results from improper neural tube closure during development.
What are fetal alcohol spectrum disorders (FASDs)?
FASDs are a range of effects that can occur in an individual whose mother consumed alcohol during pregnancy
These can include physical, behavioral, and learning problems.
What is autism spectrum disorder (ASD)?
ASD is a developmental disorder characterized by challenges with social interaction and communication
It has various etiologies and comorbidities.
Define neurogenesis.
Neurogenesis is the process by which new neurons are formed in the brain
It involves neural stem cells and plays a crucial role in brain development.