Behavioral Science: Genetics in Psychiatry Flashcards Preview

MS2 Unit 3 > Behavioral Science: Genetics in Psychiatry > Flashcards

Flashcards in Behavioral Science: Genetics in Psychiatry Deck (14):
1

Important genes in schiz

COMT
Tyrosine hydroxylase
Dopamine D2 receptor
Dopamine D3 receptor

2

What do abnormalities in COMT and DAR cause?

Hypofrontality (as seen in schizophrenia)
- we don't know what causes the limbic hyperactivity

3

Important genes in ADHD

DRD4
DRD5

4

Important genes in MDD

DAT
DRD4
COMT

5

What parts of the brain have high/low activity in MDD?

High activity: VMPFC, amygdala
Low activity: DLPFC

6

What does hyperfunctioning in limbic pathways cause?

Panic, worry, obsession, depression

7

Important genes in MDD/Anxiety/ED/Bipolar

5HT-2A 102 T/C
5HTTLPR promoter
TPH

8

What does hypofunctioning in the frontocortical pathways cause?

ADHD
Depression

9

DA and NE dysfunction lead to...

Reduced positive affect: depressed mood, loss of happiness, loss of interest/pleasure, loss of energy/enthusiasm, decreased alertness, decreased self confidence

10

5HT and NE dysfunction lead to...

Increased negative affect: depressed mood, guilt/disgust, hostility, irritability, loneliness

11

COMT Met alleles -->

low degradation --> increased NE and anxiety in limbic areas

12

COMT Val alleles -->

high degradation --> low NE in cortex, less attention

13

What does memorizing do to the empathic response?

Decreases it

14

What might the brain of a low-empathy person look like?

Overactive cingulates, hypoactive MPFC