Flashcards in Behavioral Science: Genetics in Psychiatry Deck (14):
Important genes in schiz
Dopamine D2 receptor
Dopamine D3 receptor
What do abnormalities in COMT and DAR cause?
Hypofrontality (as seen in schizophrenia)
- we don't know what causes the limbic hyperactivity
Important genes in ADHD
Important genes in MDD
What parts of the brain have high/low activity in MDD?
High activity: VMPFC, amygdala
Low activity: DLPFC
What does hyperfunctioning in limbic pathways cause?
Panic, worry, obsession, depression
Important genes in MDD/Anxiety/ED/Bipolar
5HT-2A 102 T/C
What does hypofunctioning in the frontocortical pathways cause?
DA and NE dysfunction lead to...
Reduced positive affect: depressed mood, loss of happiness, loss of interest/pleasure, loss of energy/enthusiasm, decreased alertness, decreased self confidence
5HT and NE dysfunction lead to...
Increased negative affect: depressed mood, guilt/disgust, hostility, irritability, loneliness
COMT Met alleles -->
low degradation --> increased NE and anxiety in limbic areas
COMT Val alleles -->
high degradation --> low NE in cortex, less attention
What does memorizing do to the empathic response?