Benzodiazepines Flashcards
1
Q
Midazolam
A
Onset: 30-60 seconds
Peak: 3-5 minutes
Duration: 15-80 minutes
Half Life: 2 hours
Mechanism: Alpha protein on the GABA receptors in the cerebral cortex. Hyperpolarizes the cell
pKa: ~6 makes it water soluble in the vial and lipid soluble in the blood.
2
Q
Lorazepam
A
Onset: 1-2 minutes
Peak: 20-30 minutes
Duration: 6-10 hours
Half life: 15 hours
3
Q
Diazepam
A
Half life: 30 hours
