Beta agonists + Indirect acting sympathomimetics + DA

Question 1

isoproterenol effects on blood pressure

Answer 1

decrease due to B2 vasodilation of skeletal muscle

Question 2

isoproterenol effect on HR

Answer 2

decreased BP causes reflexive increase in HR

Question 3

large doses of isoproterenol cause

Answer 3

tachycardia, palpitations, arrhythmias

Question 4

isoproterenol is used for

Answer 4

emergency MI and complete heart block

Question 5

B1 agonist with some effect on alpha receptors

Answer 5

Dobutamine

Question 6

dobutamine half life and dosing

Answer 6

2 minutes, continuous infusion

Question 7

dobutamine cardiac effects

Answer 7

1. positive inotropic effect
2. increases CO
3. increases contractility

Question 8

dobutamine is used for

Answer 8

cardiac stress tests if pt can’t exercise

Question 9

continuous IV dobutamine is used to

Answer 9

increase CO in cardiogenic shock and CHF

Question 10

patients with a history of htn + dobutamine _____

counteract this by _______

Answer 10

increased BP and HR

slow down the infusion

Question 11

selective B2 agonists (2)

Answer 11

Terbutaline

Albuterol

Question 12

B2 agonists (Terbutaline, Albuterol) treat

Answer 12

asthma

Question 13

B2 agonist (Terbutaline, Albuterol) side effect, esp if given oral

Answer 13

HA, tachycardia, tremor

Question 14

B3 adrenergic receptor agonists

Answer 14

mirabegron

Question 15

mirabegron treats

Answer 15

overactive bladder

Question 16

mirabegron side effects

Answer 16

N/D/C, HA, htn, dizziness, sinus tachycardia

Question 17

low doses of dopamine

Answer 17

1. activate D1 receptors –> increased blood to kidneys

2. dilate mesenteric and coronary arteries

Question 18

high doses of dopamine have effects similar to

Answer 18

epinephrine due to release of NE —> a1

Question 19

higher concentrations of dopamine stimulate _____ in the heart, causing ______

Answer 19

B1

positive inotropic and chonotropic effect

Question 20

side effects of DA

Answer 20

N/V, HA, tachycardia, angina, arrhythmia, peripheral vasoconstriction

Question 21

selective D1 receptor agonist

Answer 21

fenoldopam

Question 22

main use for fenoldopam

Answer 22

rapid decrease of BP in severe HTN by dilating vascular beds

Question 23

amphetamine MOA

Answer 23

indirect acting sympathomimetic increases release of NE and DA, esp in CNS

Question 24

Amphetamine is a

Answer 24

CNS stimulant

Question 25

bad effects of amphetamine at high doses

Answer 25

cerebral hemorrhage convulsions coma

Question 26

ADHD drug similar MOA to amphetamine

Answer 26

methylphenidate

Question 27

cocaine MOA

Answer 27

inhibits reuptake of DA and NE into nerve terminals | shorter acting and more intense than amphetamine

Question 28

cocaine can cause

Answer 28

htn, stroke (healthy young adults) | MI, arrhythmias, psychosis

Question 29

clincal use for cocaine

Answer 29

vasoconstrict and anesthetize before nose surgery

Question 30

tyramine MOA

Answer 30

indirect acting increases release of catecholamines from nerve terminals displaces NE from vesicles, forms false transmitter octopamine

Question 31

octopamine

Answer 31

the false neurotranmitter tyramine creates

Question 32

because tyramine forms octopamine, ______ occurs to effects of tyramine

Answer 32

tachyphylaxis

Question 33

why isn't tyramine absorbed orally

Answer 33

hydrolyzed by monamine oxidase in GI tract and liver

Question 34

treatment for depression with monamine oxidase inhibitor + tyramine

Answer 34

tyramine might actually get absorbed causing severe hypertensive crisis