Bio Med MID SEMESTER EXAM Flashcards

(85 cards)

1
Q

THE INTEGUMENTARY SYSTEM ORGANS

A

a) Skin
b) Hair
c) Glands (sweat and oil glands)
d) Nails

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2
Q

Layers / structure of the skin:

A

Epidermis
Dermos
Sub Cutaneous tissue ( Hypo dermis)

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3
Q

CELLS OF THE EPIDERMIS

A

Keratinocytes
Melanocytes
Langerhan cells
Merkel’s cells

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4
Q

LAYERS OF THE EPIDERMIS

A
  1. Stratum basale
  2. Stratum spinosum
  3. Stratum granulosum
  4. Stratum lucidum
  5. Stratum corneum
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5
Q

Oldest layer of Epidermis

A

Statum Corneum

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6
Q

Langerhans cells are most abundant here

A

Stratum Spinosum

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7
Q

 Melanocytes are found in this layer

A

Stratum Basale

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8
Q

 Keratinocytes flatten out, and their nuclei and organelles begin to
disintegrate
 Cells produce waterproofing substance

A

Stratum Granulosum (Granular Layer) :

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9
Q

Stratum Corneum (Horny Layer) :

A

 Outermost layer
 Consists of layers of dead cells, filled with keratin.
 Cells at the surface exfoliate as tiny scales called ‘dander’

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10
Q

Fibres in the dermis:

A

 Collagen and elastic fibres are found throughout the dermis
 Collagen fibres are responsible for the toughness of the dermis
 They attract and bind water to keep the skin hydrated
 Elastic fibres give elasticity to the skin when we are young

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11
Q

HAIR FOLLICLE

A

Extend from the epidermal surface into the dermis

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12
Q

Small bands of smooth muscles called “…………“connect each side of the
hair follicle to the dermal tissue - when these muscles contract the hair is
pulled upright.

A

Erector Pilli

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13
Q

FUNCTIONS OF THE SKIN

A

Sensation
 Protection
 Maintain body temperature
 Excretion
 Absorption
 Vitamin D synthesis
 Blood reservoir

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14
Q

Burns considered critical if:

A

Over 25% of the body has second-degree burns
* Over 10% of the body has third-degree burns
* There are third-degree burns on face, hands, or feet

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15
Q

Tissues

A

groups of cells that are similar in structure and
perform a common or related function.
 The four major types of tissues in the body are:
 Epithelial tissue
 Connective tissue
 Muscle tissue
 Nerve tissue

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16
Q

Avascular but innervated

A

contains no blood vessels but
supplied by nerve fibers

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17
Q

Simple cuboidal Epithelium

A

Protection - Absorbtion- Excretion - Filtration -Secretion

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18
Q

Simple Epithelium :
Stratified Epithelium :

A

Simple : one layer of cells
Stratified : more then one layer

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19
Q

Simple Squamous Epithelium

A

 It is a single layer of thin squamous cells (flattened, like fish
scales) resting on a basement membrane.
 The cells fit closely together.

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20
Q

Simple Squamous Epithelium : Location?
Function?

A

Air sacs (alveoli) of lungs where oxygen and carbon dioxide are
exchanged.
 Capillaries where filtration takes place (kidney glomeruli).
 Lining of heart, blood vessels, lymphatic vessels, and
serosa
Function :
 Allows for easy diffusion and filtration

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21
Q

Stratified Squamous Epithelium
LOCATION / FUNCTION

A

It consists of several layers of squamous cells
Location
 Skin has keratinised, stratified epithelium
 The lining of the mouth cavity, oesophagus and vagina have
non keratinised, stratified epithelium
Function
 Protect underlying areas from abrasion

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22
Q

Simple Cuboidal Epithelium
Location

A

Single layer of cube-like cells with large, spherical central
nuclei
 Present in kidney tubules, ducts and secretory glands e.g.
salivary glands, pancreas , and ovary surface.

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23
Q

Stratified Cuboidal Epithelium

A

Usually has just two layers with (at least) the surface
cells being cuboidal in shape.
 They are rare in the body.
 They may also line the ducts of large glands

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24
Q

Simple Columnar Epithelium

A

Simple columnar epithelium is made up of a single layer of tall
cells that fit closely together, many contain cilia.
Function in absorption and secretion

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25
Cillia
Cilia help move substances through internal passageways
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Ciliated Columnar Epithelium Location ? Function?
It is also found in the uterus and Fallopian tubes of females. trachea, the air passages like the nose, large bronchi Function: To propel / move along  The movement of the cilia propel the ovum to the uterus.  Propels mucus in the respiratory passages
27
Pseudostratified Columnar Epithelium
"FAKEstatified" Single layer of cells with different heights; some do not reach the free surface  Nuclei are seen at different layers  Present in the male sperm-carrying ducts (non ciliated) and trachea (ciliated)
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Glandular Epithelium
Classified by:  Site of product release – endocrine or exocrine  Relative number of cells forming the gland – unicellular or multicel
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Endocrine Glands
Ductless glands that produce hormones  Secretions include amino acids, proteins, glycoproteins, and steroids
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Exocrine Glands
Examples include mucous, sweat, oil, and salivary glands.  The only important unicellular gland is the goblet cell  Multicellular exocrine glands are composed of a duct and secretory unit
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Structural Elements of Connective Tissue
Cells  Fibroblasts, chondroblasts, osteoblasts, and hematopoietic stem cells. 2. Ground substance  Unstructured material that fills the space between cells. 3. Fibers  Collagen, elastic, or reticular
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Ligament? Tendon?
Ligament is bone to bone Tendon is Muscle to bone
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Cells of the Connective tissue
Chondroblasts - Cartilage Osteoblasts - Bone Fibroblasts - collagen Hematoietic stem cells - blood cells Fat Cells/Adipocytes - fat storage
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Connective Tissue: Cartilage derived from?
Derived from chondrocytes  Contains no blood vessels  Derives nutrients from matrix by diffusion Functions  Provide flexible support and tensile strength  Provides framework for developing embryo
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Erythrocytes  Leukocytes  Thrombocytes
Erythrocytes (red blood cells),  Leukocytes (white blood cells) and  Thrombocytes (platelets)
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 Epithelial membranes -
Sheet of epithelial cells over a thin layer of loose connective tissue
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Mucous membranes:
line body cavities or canals that open to the exterior ◼ Example: throat, nose, mouth, urethra, rectum, vagina, etc. ◼ They produce a thick, slippery liquid called mucus that protects the membranes and keeps them moist
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 Serous membranes -
line body cavities that do not open directly to the outside ◼ Serous membranes produce serous fluid which lubricates the membrane and reduces friction when organs move against each other or the cavity wall ◼ Example: Pericardium, pleural
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Synovial membranes -
line the cavities of the freely movable joints ◼ Example: the shoulder, elbow and knee ◼ secrete synovial fluid into the joint cavity which lubricates the cartilage on the ends of the bones so that they can move freely and without friction
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NUTRIENTS
Substances that promotes growth, maintenance, and repair  Major nutrients – carbohydrates, lipids, and proteins  Other nutrients nutrients – vitamins vitamins and mineral
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CARBOHYDRATES
Contain carbon, hydrogen, and oxygen Dietary sources Starch (complex carbohydrates) - grains and vegetables (bread, cereal, potatoes) Simple sugars - fruits, honey and milk Insoluble fiber - cellulose in vegetables - provides roughage Soluble fiber - pectin in apples and citrus fruits - reduces blood cholesterol levels
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Energy
Glucose is the fuel used by cells to make ATP (cellular respiration) Excess glucose is converted to glycogen or fat and stored 2. Form new compounds Combine to form
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LIPIDS
 Contain C, H, and O, but the proportion of oxygen in lipids is less than in carbohydrates  They are insoluble in water but dissolve in other lipids, and solvents like alcohol
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LIPIDS
 Contain C, H, and O, but the proportion of oxygen in lipids is less than in carbohydrates  They are insoluble in water but dissolve in other lipids, and solvents like alcohol Help absorb fat-soluble vitamins Major fuel of hepatocytes and skeletal muscle Phospholipids are essential in myelin sheaths and all cell membranes
44
Functions of fatty deposits (adipose tissue)
Protective cushions around body organs Insulating layer beneath the skin Concentrated source of energy
45
Functions of cholesterol
Stabilizes membranes Precursor of bile salts and steroid hormones
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PROTEINS
Contain carbon, hydrogen, oxygen and nitrogen; may contain sulphur and phosphorus Uses Structural materials: keratin, collagen, elastin, muscle proteins. Most functional functional molecules molecules: enzymes, enzymes, some hormones. Protein will be used as fuel if there is insufficient carbohydrate or fat available.
47
Nitrogen balance In healthy adults;
The body is in nitrogen balance when the amount of nitrogen ingested in proteins equals the amount excreted in urine and feces.
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VITAMINS
Organic compounds  Needed for growth and good health (A, B-complex, C, D, E, and K)  Crucial in helping the body use nutrients  Most function as coenzymes  Vitamins D, some B and K are synthesized in the body  All others must be ingested
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Water-soluble vitamins
B complex and C are absorbed with water B12 absorption requires intrinsic factor Not stored in the body
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Fat-soluble vitamins
A, D, E, and K bind to ingested lipids, and are absorbed with lipid digestion products Stored in the body, except for vitamin K Vitamins A, C, and E act as antioxidants
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MINERALS
Seven minerals are required in moderate amounts  Calcium, phosphorus, potassium, sulfur, sodium, chloride, and magnesium.
51
METABOLISM
It is the sum total of all the chemical reactions which occur in the human body  Two types of reactions  Anabolic reaction  Catabolic reaction
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ANABOLIC REACTIONS
Synthesis of large molecules from small ones - building up reactions Results in positive nitrogen balance Dynamic process requiring energy
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CATABOLIC REACTION
Hydrolysis of complex structures to simpler ones - breaking down reactions Results in negative nitrogen balance Releases energy
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CARBOHYDRATE METABOLISM
All carbohydrates in food is either digested to glucose or converted to glycogen in the liver  Glucose enters the cells (with the help of hormone, insulin)
55
Glycogenesis  Glycogenolysis Gluconeogenesis
 Glycogenesis – glycogen synthesis  Occurs when glucose supplies are in excess; liver and skeletal muscle.  Glycogenolysis – lysis or breakdown of glycogen  Occurs in response to low blood glucose level; in the liver, kidney and intestinal cells  Gluconeogenesis – glucose synthesis from noncarbohydrate molecules (glycerol and amino acid)  Occurs as a protective mechanism against the damaging effects of hypoglycemia (low blood glucose level); in the liver
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LIPID METABOLISM
Lipids are broken down to fatty acids and glycerol before it the enters cells Excess fatty acids and glycerol is converted into triglycerides to be stored in adipose tissue
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Lipogenesis
– synthesis of triglycerides.
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PROTEIN METABOLISM
Proteins have limited lifespan  Amino acids are the most important anabolic nutrients  They form all protein structures and bulk of the functional proteins.  Amino acids are broken and reused to build new proteins
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Excess proteins ??
Excess proteins cannot be stored, they are broken down to amino acids to be converted to fat and stored for later use
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Absorptive state:
the time during and shortly after eating  Nutrients rapidly enter blood stream from gastrointestinal tract.  Insulin directs events in this state
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Post absorptive state:
period when the gastro-intestinal tract is empty.  body reserves are broken down to supply energy.  Regulated by several hormones and sympathetic nervous system
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EXTRACELLULAR FLUID COMPARTMENTS
Interstitial fluid (ISF) – volume of fluid in the microscopic spaces between the cells 2. Plasma – volume of fluid portion of the blood within the blood vessels. 3. Transcellular Transcellular fluid – fluid in the body cavity or spaces
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COMPOSITION OF BODY FLUIDS
Solvent - water Solutes - electrolytes and non-electrolytes Electrolytes – substances that ionize in water to charged particles
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ELECTROLYTES
Electrolytes are salts, acids, and bases Electrolyte balance usually refers only to salt balance Salts enter the body by ingestion and are lost via perspiration, faeces, and urine
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Functions of electrolytes
Electrolytes are salts, acids, and bases Electrolyte balance usually refers only to salt balance Salts enter the body by ingestion and are lost via perspiration, faeces, and urine
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When there is low sodium ions in the plasma
Aldosterone is released from adrenal gland
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When there is too much sodium ions in the plasma
Increase release of hormone ADH from pituitary gland Increase in the hormone - atrial natriuretic peptide ANP from heart Reduction in aldosterone release
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Acids are chemical substances that
t donate H+ (Proton donor)
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Bases or alkali
are chemical substances that accept H+ (Proton acceptor)
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PH SCALE
pH 7 is neutral pH <7 – acidic pH > 7 – alkaline
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CONTROL OF ACID-BASE BALANCE
Normal blood pH – 7.35 – 7.45 Alkalosis – increase in pH of arterial blood >7.45 Acidosis – decrease in pH of arterial blood <7.35
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Plasma membrane
Transparent barrier that encloses cell contents Seperate the intracellular fluid with the extracellular Lipid Bio layer of phospholipids Hydrophilic - water scared
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Mitochondria and Ribosomes
Cellular respiration ATP and Protien synthesis RNA
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Endoplasmic reticulum
transport system of cells
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Golgi aparatis and Lysosomes
Pasckaging - accumilation of protiens - detoxification unit
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Centreols and cytoskeleton
mitotic spindle determins the structure and supports cell
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Periosteum
The fibrous membrane covering bone consisting of an outer fibrous layer and an inner cellular layer (cambium). The outer layer is composed mostly of collagen and contains nerve fibres that cause pain when the tissue is damaged. It also contains many blood vessels, branches of which penetrate the bone to supply the osteocytes, or bone cells.
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Medulary cavity
The medullary cavity is the hollow part of bone that contains bone marrow. The bone marrow makes blood cells and stores fat. Spongy bone (also called cancellous bone) is made up of small, needle-like pieces of bone arranged like a honeycomb.
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Bone is made up of
NERVOUS TISSUE BONY OSSEUS TISSUE CARTILAGE MUSCLES AND EPITHELEAL TISSUE IN THEI BLOOD
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EPIPHYSEAL CARTILAGE
INBETWEEN THE EPIPHYSIS AND DIAPHYSIS CARLIAGE RESPONISBLE FOR BONE GROWTH
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Wolff's Law s
It states that our bones become thicker and stronger over time to resist forces placed upon them and thinner and weaker if there are no forces to act against. This principle is important for preventing injuries. A thicker bone is harder to break.
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FOOT BONES
TALUS AND CALCANEOUS
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