BIOC Lecture 116

Question 1

Kinesin

Answer 1

motor protein, moves anterograde (-ve to +ve, towards cell periphery)
2 light chains and 2 heavy chains assembly to form a dimer with 2 heads
moves alone MT

Question 2

Dynein

Answer 2

motor protien, moves retrograde (+ve to -ve, to cell body) 2 or 3 heads with ATPase activity

Question 3

spectrin

Answer 3

alpha and beta chains form a dimer, contain triple a helical repeat

has actin binding sites

spokes, fences

Question 4

complexes

Answer 4

ankryin (2.1 band) links membrane spectrin via band 3 and PS

Question 5

hubs

Answer 5

linker (4.1 band) linkes membrane to spectrin via glycophorin and PIP2

short actin MF, adducin, band 4.1, tropomyosin, tropomodulin

Question 6

hereditary spherocytosis

Answer 6

absence of band 3, spherical

Question 7

hereditary elloptpcytosis

Answer 7

abnomailities in spectrin, band 4.1, GPC