Biochem Flashcards
(21 cards)
Makes DNA active
Acetylation
Makes DNA mute
Methylation
Purines
A, G - 2 rings
“PURAG”
“PURe As Gold”
Pyimidines
C,U,T - 1 ring
“CUT the PY”
PyriCUT
Deamination of cytosine makes?
Uracil
Thyimine has?
Methyl
Between Thymine and Uracil,which is found in DNA and which is found in RNA?
Uracil in RNA “uRacil in RNA”
thymine in DNA
Amino acids necessary for purine synthesis
Glycine
Aspartate
Glutamine
GAG
Which is a stronger bond and thus has a higher melting temperature between CG and AT?
CG has 3 H bonds and is thus stronger
AT has only 2 H bonds
Only histone that is not in the nucleosome core?
H1
Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Inhibits ribonucleotide reductase.
Hydroxyurea
Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Blocks de novo purine synthesis.
6-Mercaptopurine
Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Inhibits thymidilate synthase
5-fluorouracil
Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Ihibits dihydrofolate reductase
Methotrexate
Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Inhibits bacterial dihydrofolate reductase
Trimethoprim
Purine salvage deficiency. Absence of HGPRT which converts hypoxanthine to IMP and Guanine to GMP.
Lesch-Nyhan Syndrome
Purine salvage deficiency. Results in escess uric acid production and de novo purine synthesis
Lesch-Nyhan syndrome
Mutation in DNA. Same aa, base change in 3rd position of codon (tRNA wobble)
Silent Mutation
Mutation in DNA. CHANGED aa
Missense mutation
Mutation in DNA. Change resulting in early stop codon
Nonsense mutation
“stop the nonsense!”
Mutation in DNA. Change resulting in misreading of all nucleotides downstream, usually resulting in a truncated, non functional protein
Frameshift mutation
