Biochem Flashcards
(23 cards)
Define Acid
Donates a proton
Define Base
Accepts a proton
Weak Acid or Weak Base
Does not completely dissociate in a solution
Neutralization Reaction
Acid and base added together react to form a salt and water
Equilibrium constant
K
Dissociation constant
Kd
pH
Measure hydrogen activity
= -log [H+]
pKa
Measures the strength of an acid
pKa < 1
Measurement means this is a strong acid
pKa > 1
Measurement means this is a weak acid
Henderson-Hasselbalch equation
Used to calculate the pH of a solution given a known concentration of acid and a known concentration of base
Equation used for creating buffers
Henderson-Hasselbalch equation
Environmental sources of acidosis
Phosphate or sulfate compounds
Grain-enriched diet
Diabetes
Starvation
Toxin ingestion
Environmental sources of alkalosis
Fruits
Vegetables
Organs which regulate acids and bases in the body
Kidneys and lungs
What gets reabsorbed by the kidneys to balance pH?
Bicarbonate HCO3
What is removed by the kidneys to be urinated?
Ammonium NH3
Protons H+
Which salts are important to regulating pH in the body?
Sodium Na+
K+
Why does phosphoric acid H3PO4 have 3 pKa’s?
Phosphoric acid H3PO4 has 3 hydrogens to donate
Intrinsic buffers
Phosphate PO4
Proteins’ amino acids
Extrinsic buffer
Converting H2CO3 to H20 and CO2
The pKa of phosphate PO4 which meets physiological conditions
pKa 7.2
Site of extrinsic buffering
The lungs