Biochem Flashcards
(17 cards)
What aa is needed for purine synthesis
Glycine
Aspartate
Glutamine
What drug inhibit pyramiding synthesis
Leflunomide - dihydroorotate DH
Methotrexate (human), trimethoprim (bacteria) pyrimethamine (Protozoa) - dihydrofolate reductase
5-fluorouracil —> 5F dUMP - thymidylate synthase
What drugs inhibit purine synthesis
6-mercaptopurine —-> azathioprine - de novo purine synthesis
Mycophenolate, ribavirin - inosine monoP DH
What drug inhibit purine and pyramiding synthesis
Hydroxyurea
What causes Lesch-Nyhan
HGPRT deficiency
- G cannot convert to GMP
- hypoxanthine cannot convert to IMP
- build up GMP and IMP –> build up uric acid
Sx of lesch-Nyhan
Hyperuricemia Gout self multilation retardation dystonia
how to tx Lesch-Nyhan
allopurinol
febuxostat
what drug inhibit topoisomerase in human
TP1 - irinotecan/topotecan
TP2 - etoposide/teniposide
what drug inhibit toposiomerase in prokaryotes
fluoroquinolone inhibit TP2 ( gyrase) and TP4
why type of DNA mutation causes Duchenne muscular dystrophy and Tay-Sach
frameshift
xeroderma pigmentosum found in what kind of DNA repair defect
nucleotide excision repair
Herediatary nonpolyposis colorectal cancer/Lynch syndrome found in what DNA repair defect
Mismatch
ataxia telangiectasia - what DNA repair defect
nonhomologous end joining
breast/ovarian cancer - what DNA repair defect
homologous recombination ( mitosis)
a-amanitin inhibits __?
RNA pol II
causes liver toxicity
actinomycin D inhibits__?
RNA pol in both prokaryote and eukaryotes
rifampin inhibits __?
DNA dependent RNA pol in prokaryote
