biochem in cell Flashcards

1
Q

“everything that living
things do can be
understood in terms of
the jigglings and
wigglings of atoms”

A

Richard Feynman
- Sperm fertilizing an
egg.

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2
Q

“Living things are composed of lifeless molecules”

A

Albert Lehninger

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3
Q

“Chemistry is the logic of biological phenomena”

A

Garrett and Grisham

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4
Q

complicated and highly organized

A

Living Organisms

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5
Q

serve functional purposes

A

Biological structures

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6
Q

actively engaged in energy
transformations

A

Living systems

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7
Q

have a remarkable capacity for self-
replication

A

Living systems

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8
Q

flows from photosynthetic organisms through
food chains to herbivores and on to carnivores at the apex of
the food pyramid

A

Solar energy

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9
Q

1st primary Producers

A

photosynthesis

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10
Q

1st primary Consumers

A

herbivores

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11
Q

2nd primary Consumers

A

Carnivores

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12
Q

Organisms capture energy in the form of special
energized molecules

A

ATP, NADPH

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13
Q

ATP structure draw

A

drawing

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14
Q

NADPH structure draw

A

drawing

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15
Q

Two complementary
polynucleotide chains running in opposite directions can pair
through hydrogen bonding between their nitrogenous bases.
Their complementary nucleotide sequences give rise to
structural complementarity.

A

DNA double helix

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16
Q

DNA double helix

A

5’ top
3’ bottom

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17
Q

Covalent bond
formation by e- pair sharing
makes _____ appropriate
for the support of life

A

H, O, C and N

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18
Q

make up 99+% of atoms in the human body

A

H, O, C and N

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20
Q

63% atoms in the human body

A

Hydrogen

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20
Q

25.5% atoms in the human body

A

Oxygen

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21
Q

9.5% atoms in the human body

A

Carbon

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22
Q

1.4% atoms in the human body

A

Nitrogen

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23
Q

What property unites H, O, C and N and renders
these atoms so appropriate to the chemistry of life?

A

ability to form covalent bonds by
electron-pair sharing

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24
Q

H-H bond

A

436 kJ/mol

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25
C-H bond
414 kJ/mol
26
C-C bond
343 kJ/mol
27
C-O bond
351 kJ/mol
28
formation by e- pair sharing
Covalent bond
29
the Units for Building Complex Structures
Simple Molecules
30
example of linear aliphatic
stearic acid
31
example of cyclic
cholesterol
32
example of branched
B-carotene
33
example of planar
chlorophyll a
34
inorganic precursors: (16-64 daltons)
carbon dioxide
35
metabolites: (50-520 daltons)
pyruvate
36
building blocks: (100-350 daltons)
alanine (amino acid)
37
macromolecules: (10^3 - 10^9 daltons)
protein
38
have a “sense” or directionality
Macromolecules and their building blocks
39
informational
Macromolecules
40
have characteristic three-dimensional architecture
Biomolecules
41
maintain biological structure and determine biomolecular interactions
weak forces
42
build proteins
Amino acids
43
are built by joining sugars together
Polysaccharides
44
polymers of nucleotides
Nucleic acids
45
hold atoms together so that molecules are formed
Covalent bonds
46
profoundly influence the structures and behaviors of all biological molecules
Weak forces
47
create interactions that are constantly forming and breaking under physiological conditions
Weak forces
48
Energies of weak forces range from
0.4 to 30 kJ/mol
49
weak forces include
- van der Waals interactions - Hydrogen bonds - ionic interactions
50
Van der Waals Interactions
0.4-4.0 kJ/mol
51
Hydrogen Bonds
12-30 kJ/mol
52
Ionic Interactions
20 kJ/mol
53
Hydrophobic Interactions
<40 kJ/mol
54
mediated by weak chemical forces
Biomolecular recognition
55
restrict organisms to a narrow range of environmental conditions
weak forces
56
contribute to the stability of proteins
Ionic bonds
57
the principle that guides the biomolecular interactions that characterize the living state.
Molecular Recognition Through Structural Complementarity
58
- A single (plasma) membrane - No nucleus or organelles
Prokaryotic cells
59
- Much larger in size than prokaryotes - 103-104 times larger! - Nucleus plus many organelles - ER, Golgi, mitochondria, etc.
Eukaryotic cells
60
a member of the coliform group of bacteria that colonize the intestinal tract of humans.
Escherichia coli or Ecoli
61
genetic elements enclosed in a protein coat.
viruses
62
not free-living organisms and can reproduce only within cells.
viruses
63
how an almost absolute specificity for their particular host cells, infecting and multiplying only within those cells.
viruses
64
known for virtually every kind of cell.
viruses
65
mobile bits of genetic information encapsulated in a protein coat.
viruses